Synthesis, Characterization and Remedial Aspect of BaTiO<sub>3</sub> Nanoparticles Against Bacteria

Raja, S. R. T.; Bheeman, Dinesh; Rajamani, Ranjithkumar; Pattiyappan, Sagadevan; Sugamaran, Sathish; Bellan, Chandar Shekar

doi:10.1166/nmb.2015.1014

Cited by 8 publications

(12 citation statements)

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“…The effect of filler was visible on 24 h more than on 12 h. In addition, the CTC images confirmed how the addition of BT provided an improvement in antibacterial properties. The images of the area covered by bacteria showed how the bacterial distribution on PLA 5% BT surfaces was in the same range of the PLA 10% BT and lower than the PLA matrix also at 12 h. The PLA 15% BT displayed the lowest amount of area covered at 12 h, and the values remained unchanged at 24 h. The antibacterial effects of BT were already reported in the literature against both Gram-positive and Gram-negative strains, and it was observed that the bacterial inhibition effect was dependent on the number of particles used [ 49 ]. The use of BT as filler in the creation of antibacterial composites has been described by Marin et al, reinforcing scaffolds of polyvinyl-siloxane scaffolds (PVS).…”

Section: Discussionmentioning

confidence: 75%

Bacteriostatic Behavior of PLA-BaTiO3 Composite Fibers Synthesized by Centrifugal Spinning and Subjected to Aging Test

Boschetto

Doan

et al. 2021

Molecules

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The present work investigated the effect of Polylactic acid (PLA) fibers produced by centrifugal spinning with incorporated BaTiO3 particles to improve their bacteriostatic behavior. The PLA matrix and three composites, presenting three different amounts of fillers, were subjected to UV/O3 treatment monitoring the possible modifications that occurred over time. The morphological and physical properties of the surfaces were characterized by different microscopic techniques, contact angle, and surface potential measurements. Subsequently, the samples were tested in vitro with human dermal fibroblasts (HDF) to verify the cytotoxicity of the substrates. No significant differences between the PLA matrix and composites emerged; the high hydrophobicity of the fibers, derived by the polymer structure, represented an obstacle limiting the fibroblast attachment. Samples underwent bacterial exposure (Staphylococcus epidermidis) for 12 and 24 h. Increasing the concentration of BT, the number of living bacteria and their distribution decreased in comparison with the PLA matrix suggesting an effect of the inorganic filler, which generates a neutralization effect leading to reactive oxygen species (ROS) generation and subsequently to bacterial damages. These results suggest that the barium titanate (BT) fillers clearly improve the antibacterial properties of PLA fibers after aging tests made before bacterial exposure, representing a potential candidate in the creation of composites for medical applications.

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Section: Discussionmentioning

confidence: 75%

Bacteriostatic Behavior of PLA-BaTiO3 Composite Fibers Synthesized by Centrifugal Spinning and Subjected to Aging Test

Boschetto

Doan

et al. 2021

Molecules

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“…Previous biological studies involving free BTO nanoparticles did not assess the cytotoxicity of BTO. , To be a potent biomaterial in the human body, the cytotoxicity of BTO-nanocomposites needs to be assessed in an appropriate cellular environment. As we studied the antibiofilm activity of BTO-nanocomposite discs against a model oral pathogen, S.…”

Section: Resultsmentioning

confidence: 99%

“…Previous biological studies involving free BTO nanoparticles did not assess the cytotoxicity of BTO. 18,19 To be a potent biomaterial in the human body, the cytotoxicity of BTO-nanocomposites needs to be assessed in an appropriate cellular environment. As we studied the antibiofilm activity of BTO-nanocomposite discs against a model oral pathogen, S. mutansand this work is an extension to our recent work on BTO-dental crown composites, 23 we determined the cytotoxicity of BTO-nanocomposite discs against human gingival cells (HGFs and HGKs).…”

Section: ■ Resultsmentioning

confidence: 99%

“…There have also been attempts to utilize BTO-based systems for antibacterial and oral applications. For example, the bactericidal activity of BTO as free nanoparticles at high concentration in solution has been tested. , Recently, a BTO-embedded surface was tested against Escherichia coli using reactive oxygen species (ROS) generated by ferroelectric and photocatalytic routes. , Additionally, tooth whitening via piezocatalysis has been reported using poled BTO nanoparticles in liquid form . We also recently utilized a BTO-embedded dental crown composite to develop a self-powered smart dental implant system for in situ photo-biomodulation therapy by utilizing its piezoelectrical property .…”

Section: Introductionmentioning

confidence: 99%

“…For example, the bactericidal activity of BTO as free nanoparticles at high concentration in solution has been tested. 18,19 Recently, a BTO-embedded surface was tested against Escherichia coli using reactive oxygen species (ROS) generated by ferroelectric and photocatalytic routes. 20,21 Additionally, tooth whitening via piezocatalysis has been reported using poled BTO nanoparticles in liquid form.…”

Section: ■ Introductionmentioning

confidence: 99%

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Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications

Dhall

Islam

Park

et al. 2021

ACS Appl. Mater. Interfaces

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Advances in microelectronics and nanofabrication have led to the development of various implantable biomaterials. However, biofilm-associated infection on medical devices still remains a major hurdle that substantially undermines the clinical applicability and advancement of biomaterial systems. Given their attractive piezoelectric behavior, barium titanate (BTO)-based materials have also been used in biological applications. Despite its versatility, the feasibility of BTO-embedded biomaterials as anti-infectious implantable medical devices in the human body has not been explored yet.Here, the first demonstration of clinically viable BTO-nanocomposites is presented. It demonstrates potent antibiofilm properties against Streptococcus mutans without bactericidal effect while retaining their piezoelectric and mechanical behaviors. This antiadhesive effect led to ∼10-fold reduction in colony-forming units in vitro. To elucidate the underlying mechanism for this effect, data depicting unfavorable interaction energy profiles between BTO-nanocomposites and S. mutans using the classical and extended Derjaguin, Landau, Verwey, and Overbeek theories is presented. Direct cell-to-surface binding force data using atomic force microscopy also corroborate reduced adhesion between BTO-nanocomposites and S. mutans. Interestingly, the poling process on BTO-nanocomposites resulted in asymmetrical surface charge density on each side, which may help tackle two major issues in prostheticsbacterial contamination and tissue integration. Finally, BTO-nanocomposites exhibit superior biocompatibility toward human gingival fibroblasts and keratinocytes. Overall, BTO-embedded composites exhibit broad-scale potential to be used in biological settings as energy-harvestable antibiofilm surfaces.

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A review of advances in multifunctional XTiO3 perovskite-type oxides as piezo-photocatalysts for environmental remediation and energy production

Djellabi

Ordonez

Conte

et al. 2022

Journal of Hazardous Materials

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Synthesis, Characterization and Remedial Aspect of BaTiO₃ Nanoparticles Against Bacteria

Cited by 8 publications

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Bacteriostatic Behavior of PLA-BaTiO3 Composite Fibers Synthesized by Centrifugal Spinning and Subjected to Aging Test

Bacteriostatic Behavior of PLA-BaTiO3 Composite Fibers Synthesized by Centrifugal Spinning and Subjected to Aging Test

Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications

A review of advances in multifunctional XTiO3 perovskite-type oxides as piezo-photocatalysts for environmental remediation and energy production

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Synthesis, Characterization and Remedial Aspect of BaTiO3 Nanoparticles Against Bacteria

Cited by 8 publications

References 0 publications

Bacteriostatic Behavior of PLA-BaTiO3 Composite Fibers Synthesized by Centrifugal Spinning and Subjected to Aging Test

Bacteriostatic Behavior of PLA-BaTiO3 Composite Fibers Synthesized by Centrifugal Spinning and Subjected to Aging Test

Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications

A review of advances in multifunctional XTiO3 perovskite-type oxides as piezo-photocatalysts for environmental remediation and energy production

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Synthesis, Characterization and Remedial Aspect of BaTiO₃ Nanoparticles Against Bacteria