Synthesis, characterization and separation of chiral and achiral diastereomers of Schiff base Pd(II) complex: A comparative study of their DNA- and HSA-binding

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

“…Previously, we have used a racemic ligand to synthesis racemic and meso forms of Pd(II) complexes and their biological activities were studied [14]. In the present study, in continuation of previous work a racemic mixture of Schiff base ligand was used to synthesis vanadium complex.…”

“…The results are expressed in terms of the mean residue ellipticity (MRE) according to Equation 5 [14,39]:…”

“…HSA binding studiesA stock solution of HSA was prepared by dissolving the desired amount of HSA in 50 mM phosphate buffer (pH=7). The HSA stock solution was stored at 4 °C in the dark and used within 2 h. Its concentration was determined by UV-Vis spectrophotometry using the molar absorption coefficient 35700 M -1 cm -1 at 278 nm[14]. Absorption titration experiment, an operational and very easy method, was carried out to investigate the HSA-binding of complex at room temperature.…”

Cu(II) and Ni(II) Complexes of Anthracene‐Affixed Schiff Base: A Conflict between Covalent and Stacking Interactions with DNA Bases

“…The well‐known platinum‐based anticancer drugs such as cisplatin, carboplatin and oxaliplatin are effective chemotherapeutic agents that have been clinically used . However, their significant success is retarded due to some drawbacks like drug resistance, normal tissue toxicity and neurotoxicity . The proposed Cu(II) or Ni(II) complexes consists of two labile chlorine atoms as cisplatin analogues, illustrated promising biological properties as well as chemotherapeutic potentials .…”

Antimicrobial and antiprotozoal activities of silver coordination polymers derived from the asymmetric halogenated Schiff base ligands

“…[ 68 ] The FT‐IR spectra of ligands also exhibited a broad absorption band in ∼3400 cm −1 , characteristic of the stretching vibration of the phenolic OH group. [ 69 ] Also, the detection of new low absorption bands at ~518 cm −1 and ~476 cm −1 that were assigned to ν (MN), ν (MO), respectively, confirmed that O and N atoms are coordinated to Ag(I) atom.…”