Synthesis, characterization, and spectroscopic studies of tetradentate Schiff base chromium(III) complexes

Aranha, Pedro Esteves; Santos, Mírian dos; Romera, Sandra; Dockal, Edward R.

doi:10.1016/j.poly.2006.11.005

Cited by 165 publications

(81 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The singlets for the -COCH 3 group were observed at 5.10 and 5.12 ppm and the singlets for the -CNCH 3 group were observed 1.15 and 1.18 ppm. These data are in agreement with previously reported for similar compounds and confirmed the suggested formulation of the ligands [23,34]. Magnetic studies: The room temperature magnetic moments of the complexes showed that all of the complexes are paramagnetic.…”

Section: Synthesis Of Schiffsupporting

confidence: 92%

See 1 more Smart Citation

4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

Karipçin

Özmen

Culu

2012

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

The synthesis of two new ligands 4,4'-(diphenylmethane-4,4'-diyldinitrilo)dipentan-2-one (H 2 L 1 ) and 4,4'-(diphenylether-4,4'-diyldinitrilo)dipentan-2-one (H 2 L 2 ) is reported. The ligands have two acetylacetone subunits separated by diphenylmethane or diphenylether group. The ligands form stable dinuclear complexes with Ni(II) and Cu(II) ions. Ligands and their complexes were characterized by elemental analysis, m.p., IR, molar conductivity and magnetic moment measurements. The interaction between these compounds with DNA has also been investigated by agarose gel electrophoresis, we found that the nickel(II) and copper(II) complexes can cleave supercoiled pBR322 DNA to nicked and linear forms. The copper(II) complexes with H 2 O 2 as a cooxidant exhibited the strongest cleaving activity. The free ligands were also characterized by 1 H NMR spectra.

show abstract

Section: Synthesis Of Schiffsupporting

confidence: 92%

“…The free ligands exhibit the characteristic C=O band in 1613-1608 cm −1 region. The C=N stretching frequencies are in the 1566-1560 cm −1 region as reported for similar ligands [33,34]. The low energy position of the C=N band could be attributed to its involvement in conjugation with the aromatic system.…”

Section: Synthesis Of Schiffsupporting

confidence: 71%

4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

Karipçin

Özmen

Culu

2012

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…Crystal structures of complexes [1][2][3][4]. Structures of the four complexes are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Hydrazide-hydrazone derivatives are an important class of biologically active molecules, which have attracted the attention of medicinal chemists due to their wide-ranging pharmacological properties and their potential application as antitumor, antineoplastic, antiviral and anti-inflammatory agents (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand

et al. 2017

View full text Add to dashboard Cite

Abstract. The reaction of divalent transition metal salts and (E)-N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (penh) led to the formation of [Mn(penh) 2 ] (complex 1), [Co(penh) 2 ] (complex 2), [Cu(penh) 2 ] (complex 3) and [Cd (penh) 2 ] (complex 4) complexes. The four complexes were characterized using elemental analyses, infrared spectra and single-crystal X-ray diffraction analyses. Subsequently, the complexes were used for in vitro cell level experiments to determine potential antitumor effects. The results demonstrated that the complexes exhibited a similar structure; however, they were crystallized with distinct space groups. In comparison with the uncomplexed penh ligand, all four complexes were able to markedly decrease the proliferation rate of various types of tumor cell, including the human lung cancer cell line A549, human gastric cancer cell line BGC823 and human esophageal cancer cell line Eca109, in a concentration-dependent manner. Furthermore, the complexes promoted tumor cell apoptosis, as demonstrated in the apoptosis assay, and this was confirmed using electrophoresis. IntroductionHydrazide-hydrazone derivatives are an important class of biologically active molecules, which have attracted the attention of medicinal chemists due to their wide-ranging pharmacological properties and their potential application as antitumor, antineoplastic, antiviral and anti-inflammatory agents (1-6).In particular, aroylhydrazone complexes of transition metals are known to provide useful models for the elucidation of the underlying molecular mechanism of enzyme inhibition by hydrazine derivatives (7) and for their potential pharmacological application (8,9). Hydrazone derivatives of isoniazid and other hydrazides have been reported to exhibit marked antimicrobial activity (10-14). Furthermore, a number of substituted hydrazone derivatives have been synthesized and evaluated for their antitumor activity, with certain promising results having been reported (15-17).The aim of the present study was to develop potent anticancer agents. (E)-N'-(1-(pyridin-2-yl)ethylidene) nicotinohydrazide (penh), and [Mn(penh) 2 ] (complex 1), [Co (penh) 2 ] (complex 2), [Cu(penh) 2 ] (complex 3) and [Cd(penh) 2 ] (complex 4) metal complexes were synthesized, and their cytotoxicity against human lung cancer (A549), human gastric cancer (BGC823) and human esophageal cancer (Eca109) cell lines was investigated. Materials and methodsMaterials. All starting materials were obtained commercially and used as received. The A549 human lung cancer, BGC823 human gastric cancer and Eca109 human esophageal cancer cell lines were obtained from the Cell Culture Center of the Basic Institute of Medical Sciences (Peking Union Medical College, Beijing, China). Cell culture reagents were purchased from Gibco (Thermo Fisher Scientific, Inc., Waltham, MA, USA). An Annexin V/propidium iodide (PI) double staining kit was purchased from BD Biosciences (Franklin Lakes, NJ, USA). MTT and dimethyl sulfoxide (DMSO) were purchased from Sigma-Aldrich (Merc...

show abstract

“…Transition metal complexes of azomethines have photochemical, catalytic, medicinal and electrochemical applications [1][2][3]. Tetradentate ONNO type Schiff bases have been reported for designing macrocyclic biomolecules that help in understanding biological processes [4,5]. Palladium(II) complexes have been investigated for its catalytic activity [6], photoluminescence properties as well as antitumor, anti-HIV and antimicrobial activities [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, X-Ray Diffraction Studies and Biological Properties of Ni(II) and Pd(II) Complexes of Tetradentate Schiff Bases

Shaikh¹

2018

Asian J. Chem.

View full text Add to dashboard Cite

INTRODUCTIONSchiff bases have an important position in the development of coordination chemistry due to their synthetic accessibility and physico-chemical properties. Transition metal complexes of azomethines have photochemical, catalytic, medicinal and electrochemical applications [1][2][3]. Tetradentate ONNO type Schiff bases have been reported for designing macrocyclic biomolecules that help in understanding biological processes [4,5]. Palladium(II) complexes have been investigated for its catalytic activity [6], photoluminescence properties as well as antitumor, anti-HIV and antimicrobial activities [7].The reactions of tetradentate Schiff bases acquired from salicylaldehyde and diamines are a subject of interest of many authors [8,9] due to the ease of preparation and variable geometries. In the present paper, an attempt has been made to synthesize Ni(II) and Pd(II) complexes of tetradentate Schiff bases and further investigate the structure these complexes by spectral characterization and powder X-ray diffraction studies. EXPERIMENTALAll the chemicals used were of analytical reagent grade purchased from SDFCL Mumbai, India and used as such without further purification. Magnetic susceptibility and electronic spectral data confirm the diamagnetic nature and square planar geometry for the complexes. The powder X-ray diffraction data suggested monoclinic crystal system for these complexes. The ligands and their metal complexes have been screened for antimicrobial activities.

show abstract

Synthesis, characterization, and spectroscopic studies of tetradentate Schiff base chromium(III) complexes

Cited by 165 publications

References 51 publications

4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand

Synthesis, Characterization, X-Ray Diffraction Studies and Biological Properties of Ni(II) and Pd(II) Complexes of Tetradentate Schiff Bases

Contact Info

Product

Resources

About