Synthesis, Characterization, and Study of Antibacterial Activity of Some New Formazan Dyes Derivatives, Derived from 2-Mercapto Benzoxazole

Design, Synthesis, Computational Docking and Biological Evaluation of Novel 4-Chloro-1,3-Benzoxazole Derivatives as Anticancer Agents

“…On purpose, reaction mass was added to ice-cold water, which was then acidified with glacial aceticacid. Finally the procured solid was further filtered, dried and recrystallized [19] . Yield (95%), M. Ethyl chloroacetate was added drop wise in the presence of K 2 CO 3 after completely dissolving the 2-mercaptothiozole in acetone upon continuous stirring in a reaction flask.…”

“…After 4 hours, 100 mL of DMSO was added to each well to dissolve the formazan crystals, and using a microplate reader, the absorbance at 570 nm was measured. The following formulae were used to calculate the cytotoxicity: discussions A cyclized product of chloro substituted 1, 3-benzoxazole-2-thiol 2 compound has been prepared from 4-Chloro-2-amino-phenol by treating it with carbon disulphide and potassium hydroxide in the presence of methanol [19] .The SH group which is present in the compound 2 was undergo substitution reaction with ethyl chloroacetate with the addition of acetone to produce thio ether product ethyl [(4-chloro-1, 3-benzoxazol-2-yl) sulfanyl] acetate 3 [20] . A further treatment of compound 3 with hydrazine hydrate led to the formation of peptide or amide bond formation by the elimination of ethyl alcohol to ptoduce an intermediate 2-[(4-chloro-1,3benzoxazol-2-yl)sulfanyl]acetohydrazide 4 [21] .…”

Novel Formazan Derivative: Synthesis, Characterization, Anti-breast Cancer and Antioxidant Investigation

“…Formazan compounds are an important and colored substances that emanate from the conjugated double bonds and they contain the chain (-N-C=N-NH-) (9). Formazans were extensively researched due to their biological and pharmacological effects such as antibacterial (10), anti-parkinsonian (11), antimicrobial (12), anti-fertility (13), antifungal, anti-hyperglycemic (14), anticonvulsant (15), anti-tubercular (16), anticancer (17) and anti-HIV (18).…”