Synthesis, Characterization and Superoxide Dismutase Actwity of the Manganese(ii) Mixed Ligand Complexes Containing Sulfathiazole

Anacona, J.R.; Dı́az, Jesús

doi:10.4067/s0717-97072008000400014

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…The electronic spectra of the Schiff base ligand and its metal complexes were recorded in DMSO solution and are presented in Table 6. The absorption peaks at the region of 361 and 391 nm of high intensity for ligand are attributable to intraligand n → * transitions of azomethine and lactam carbonyl group [39,40]. Similar peaks at 268 and 310 nm for the ligand are assignable to intraligand → * transitions.…”

Section: Electronic Absorption Spectramentioning

confidence: 87%

Spectral Investigation andIn VitroAntibacterial Evaluation of Ni^IIand Cu^IIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Chaudhary

Mishra

2015

Journal of Chemistry

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Two new metal complexes of general formula M(Haαft)2[M =NiIIandCuII] of asymmetrical Schiff base ligand (HL = Haαft) derived from amoxicillin andα-formylthiophene have been prepared and characterized by various physicochemical and spectral techniques. Molar conductance measurement indicates nonelectrolytic nature of the metal complexes. FT-IR spectral study reveals the ligation of metal ions at two different nitrogen [NN] donor sites of Haαft. FT-IR and electronic absorption spectral evidences suggest distorted tetrahedral and square planar geometry forCuIIandNiIIcomplexes, respectively. The structure optimization by molecular mechanics (MM) force field calculation through ArgusLab 4.0.1 version software also supports the concerned geometry of the complexes. The cell dimensions as suggested by XRPD study,a(6.753 Å),b(13.904 Å),c(20.122 Å),α(142.76°),β(106.580°), andγ(72.4343°) forCuIIanda(24.2547 Å),b(6.6371 Å),c(5.5047 Å) (α=β=γ= 90°) forNiIIcomplexes, are in good agreement with their triclinic and orthorhombic crystal systems. Particle size calculation by Scherrer’s formula indicates nanocrystalline nature of the complexes. The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2complexes against four clinical pathogenic bacteria, namely,E. coli,P. vulgaris,P. aeruginosa, andS. aureus, though being less active than the standard drug amikacin.

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Section: Electronic Absorption Spectramentioning

confidence: 87%

Spectral Investigation andIn VitroAntibacterial Evaluation of Ni^IIand Cu^IIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Chaudhary

Mishra

2015

Journal of Chemistry

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“…Among the reported mimics, the highest SOD-like activity is only 20% of the bovine erythrocyte Cu, Zn-SOD [28]. Along with copper, some of the metals such as iron [29], manganese [29,30], ruthenium [31], and cobalt [32] show a marked SOD activity and seem to retain it in living cells which has been reported [33]. Molecular dynamics in computational chemistry track precise dynamics in atomic detail.…”

Section: Introductionmentioning

confidence: 89%

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Savithri

Kumar

Vivek³

et al. 2018

International Journal of Spectroscopy

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A bidentate (N- and O-) imine-based ligand(L1)and its metal complexes of types [CuII(L1)2](C1), [CuII(L1)(Phen)](C2), [CoIII(L1)2](C3), and [CoIII(L1)(Phen)](C4)(L1= 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes.In vitrobioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus- (CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively byKbandKsvvalues which revealed a higher binding affinity for C2and C4as compared to C1and C3. In addition, the scavenging superoxide anion free radical (O∙-2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used.

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“…Metals provide templates for synthesis, but they also introduce functionalities that enhance drug delivery vectors [54]. Metals are biologically inert, and many organic drugs require interactions with metals for optimal activity [55,56]. erefore, attempts were made to explore the antimicrobial activity of ligand (3), and its complexes (4) and (5).…”

Section: Antibacterial Activity Studymentioning

confidence: 99%

Coordination Chemistry, Antibacterial Screening, and In Silico ADME Study of Mononuclear NiII and CuII Complexes of Asymmetric Schiff Base of Streptomycin and Aniline

Chaudhary

Guragain

2022

Journal of Chemistry

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Two novel metal complexes, that is, Ni (StmAn)2(4) and Cu (StmAn)2(5), were synthesized from unsymmetrical Schiff base ligand StmAn (3). The ligand was prepared by refluxing streptomycin (2) and aniline (1). They were characterized by elemental microanalysis, conductivity measurements, and spectroscopic techniques such as 1H NMR, FT-IR, ESI-mass, and electronic absorption spectral study. Interestingly, the study revealed metal coordination through azomethine nitrogen and N-atom of NH-CH3 of N-methyl-L-glucosamine unit of streptomycin. The electronic absorption spectral study supported an octahedral geometry for complex 4 and a tetrahedral geometry for complex 5. Particle size calculation by Scherrer’s formula indicated their nanocrystalline nature. The geometry optimization of the complexes was achieved by running an MM2 job in Gaussian supported Cs-ChemOffice ultra-12.0.1 and ArgusLab 4.0.1 version software. Based on SwissADME predictions, a theoretical drug profile was generated by analyzing absorption, distribution, metabolism, excretion, and toxicity (ADMET) scores of the compounds. They were screened for in vitro antibacterial activity study against four clinical pathogens such as E. coli, S. pneumoniae, P. vulgaris, and S. aureus. Minimum inhibitory concentration (MIC) study demonstrated greater inhibitory potency of complex (4) (0.024 g/L) for S. aureus relative to ligand (3) and complex (5). Studies show that metal complexes are more toxic to bacteria.

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Synthesis, Characterization and Superoxide Dismutase Actwity of the Manganese(ii) Mixed Ligand Complexes Containing Sulfathiazole

Cited by 4 publications

References 27 publications

Spectral Investigation andIn VitroAntibacterial Evaluation of Ni^IIand Cu^IIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Spectral Investigation andIn VitroAntibacterial Evaluation of Ni^IIand Cu^IIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Coordination Chemistry, Antibacterial Screening, and In Silico ADME Study of Mononuclear NiII and CuII Complexes of Asymmetric Schiff Base of Streptomycin and Aniline

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Synthesis, Characterization and Superoxide Dismutase Actwity of the Manganese(ii) Mixed Ligand Complexes Containing Sulfathiazole

Cited by 4 publications

References 27 publications

Spectral Investigation andIn VitroAntibacterial Evaluation of NiIIand CuIIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Spectral Investigation andIn VitroAntibacterial Evaluation of NiIIand CuIIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Coordination Chemistry, Antibacterial Screening, and In Silico ADME Study of Mononuclear NiII and CuII Complexes of Asymmetric Schiff Base of Streptomycin and Aniline

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Spectral Investigation andIn VitroAntibacterial Evaluation of Ni^IIand Cu^IIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)

Spectral Investigation andIn VitroAntibacterial Evaluation of Ni^IIand Cu^IIComplexes of Schiff Base Derived from Amoxicillin andα-Formylthiophene (αft)