Synthesis, characterization and sustainable drug release activity of drug bridged diblock copolymer

Abstract

Ring opening polymerization of ε-caprolactone and tetrahydrofuran were carried out by bulk polymerization technique in the presence of a drug molecule as an initiator at 160 °C for 2 h under nitrogen atmosphere. The synthesized homo and diblock copolymer was characterized by various analytical techniques. Further, the sustainable drug release study was carried out at gastric pH of 7.2. The diblock copolymer formation was confirmed by the appearance of aromatic C=O stretching around 1680 cm −1 . Due to the hydrophilic nature the diblock copolymer exhibited lower melting temperature. The drug release study confirmed the first order drug release model.