Synthesis, characterization, and tumor selectivity of a polyphosphazene–platinum(II) conjugate

Degradable Cisplatin-Releasing Core-Shell Nanogels from Zwitterionic Poly(β -Aminoester)-Graft-PEG for Cancer Chemotherapy

“…This has been used to conjugate cisplatin to the water-soluble polymers containing multicarboxylic groups (Aronov et al 2004;Avichechter, Schechter, and Arnon 1998;Gianasi et al 1999;Jr. Bogdanov et al 1996;Lin et al 2004;Malik, Evagorou, and Duncan 1999;Rademaker-Lakhai et al 2004;Song et al 2005) such as poly(2-hydroxypropyl methacrylamide) and polyethylene glycol. Generally, those polymercisplatin conjugates had lower in vitro cytotoxicity than free cisplatin, but they showed similar or even higher in vivo anticancer activity as a result of the preferential accumulation of the conjugates in tumors via the EPR effect.…”

Design of Polyphosphazene Hydrogels with Improved Structural Properties by Use of Star‐Shaped Multithiol Crosslinkers

“…It has been reported that poly(organophosphazene) bearing hydrophobic amino acid esters and hydrophilic a-amino-v-methoxypoly(ethylene glycol) (AMPEG) groups exhibit a sol/gel transition through the physical crosslinking. [22,23] Similarly, the gelation of the present polymers can be attributed to the hydrophobic interactions between the side chain fragments of isoleucine ethyl ester and aminoethyl acrylate in the polymer solution, which may occur while the hydrophilic interactions between hydrophilic parts of the polymer are conserved. Therefore, hydrophilic and hydrophobic substituents in the polymer network govern the hydrophilic and hydrophobic balances in the polymer solution and this balance in turn controls the gelation process (T ass , T max , V max, and V 37 ).…”

Design of a novel theranostic nanomedicine: synthesis and physicochemical properties of a biocompatible polyphosphazene–platinum(II) conjugate

“…18 There are other reports on micellar block copolymers conjugated with the (dach)Pt moiety. 19,20 We have also shown in our previous reports 21,22 that polyphosphazenes conjugated with the active moiety of OX exhibited excellent tumor selectivity by enhanced permeability and retention (EPR) effect. 23 Most recently, we have also reported a micellar polyphosphazene-(dach)Pt conjugate compound, 24 which self-assembled into polymeric micelles in distilled water.…”