Synthesis, characterization, anti-bacterial, anti-fungal and nematicidal activities of 2-amino-3-cyanochromenes

Nawaz, Muhammad; Abbasi, Muhammad Waseem; Hisaindee, Soleiman

doi:10.1016/j.jphotobiol.2016.09.032

Cited by 18 publications

(14 citation statements)

References 22 publications

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“…Third corner was occupied with disc containing 50 μL of DMSO as control. Replicates were made for each bacterium, and plates were incubated for 2–4 days at 37 °C, after which, zone of inhibition was measured to the nearest mm around each disc [ 3 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

“…Antifungal activities of compounds were tested by disc diffusion method as described above. Data of antifungal activity were recorded at 5–7 days of incubation 37 °C [ 3 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

“…M. phaseolina can live in soil and dead plants. Similarly, Fusarium species, also cause root and stem diseases among different plant crops [ 3 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

et al. 2022

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Background Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts. Results Anthranilic acid complexes (1–10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV–vis spectrometry, mass spectrometry and magnetic susceptibility. The morphology and size of metal complex (1–10) particles were determined by scanning electron microscope (SEM) and the surface area was determined by BET analysis. TGA and CHN analysis data indicated that the stoichiometries of complexes were 1:2 metal/ligand except for Ag(I), Al and Bi. Furthermore, DFT study was performed to optimize the structure of selected complexes. The complexes (1–10) were evaluated for their catalytic activity in the reduction of 4-nitrophenol (4-NP), antibacterial activity against S. aureus, P. aeroginosa and E. coli as well as their antifungal activity against F. solani and A. niger. The complexes were also tested against the second-stage juveniles (J2) root-knot nematodes. Conclusion Co(II) complex 5 and Cu(II) complex 6 showed high catalytic activity for the reduction of 4-NP to 4-aminophenol (4-AP). Ag(I) complex 3 showed the best activity against the pathogens that were tested namely clinically important bacteria S. aureus, P. aeroginosa and E. coli, commercially important fungi F. solani and A. niger and J2 root-knot nematodes M. javanica.

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Section: Methodsmentioning

confidence: 99%

“…Antifungal activities of compounds were tested by disc diffusion method as described above. Data of antifungal activity were recorded at 5–7 days of incubation 37 °C [ 3 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

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Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

et al. 2022

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“…[9] Pyran is a valuable class of heterocyclic scaffolds in the field of drug discovery and pharmaceuticals. [10][11][12] Pyran widely used as antibacterial, [13] anti-HIV, [14] anti-inflammatory, [15] diuretic, [16] and anti-coagulant agents. [17] Tetrahydrobenzo[b]pyrans exhibit a broad range of anticancer activity and shown to be more potent activities against cancer cells [18][19][20][21] Figure 1.…”

Section: Introductionmentioning

confidence: 99%

An Efficient and Green Synthesis of Tetrahydrobenzo[b]Pyran Derivatives Using [(EMIM)Ac] at Room Temperature

et al. 2022

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An efficient, expedient, clean and environmental being synthesis of tetrahydrobenzo[b]pyran's twenty derivatives (4 a–t) has been reported via one‐pot three component condensation reaction of various benzaldehydes, dimedone and malononitrile in presence of ionic liquid [(EMIM)Ac] as a catalyst at ambient temperature in ethanol. Advantages of these reaction follow the principle of green chemistry, which are operational simplicity, shorter reaction time, and mild reaction conditions with high yield (78–98 %) products.

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“…Furthermore, new innovative and workable procedures for the synthesis of different heterocyclic molecules are always attractive. Benzopyran and its derivatives have appealed to the researchers from medicinal, organic, industrial and other chemical fields, due to their useful pharmacological or medicinal applications, such as anticancer [20], anti-HIV [21], antifungal [22], antiviral [23], anti-inflammatory [24], antimalarial [25] antioxidant [26] and antimicrobial [27] activities. They are also broadly used in perfumes, cosmetics, agrochemicals and in food as additives [28, 29].…”

Section: Introductionmentioning

confidence: 99%

A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation

Khumalo¹,

Maddila²,

Jonnalagadda³

2019

BMC Chemistry

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Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (1H NMR, 13C NMR, 15N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup.

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Synthesis, characterization, anti-bacterial, anti-fungal and nematicidal activities of 2-amino-3-cyanochromenes

Cited by 18 publications

References 22 publications

Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

An Efficient and Green Synthesis of Tetrahydrobenzo[b]Pyran Derivatives Using [(EMIM)Ac] at Room Temperature

A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation

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