Synthesis, characterization antibacterial and antiproliferative activity of novel Cu(II) and Pd(II) complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone

Roșu, Tudor; Pahontu, Elena Mihaela; Pasculescu, Simona; Georgescu, Rodica; Stănică, Nicolae; Curaj, Adelina; Popescu, Alina; Leabu, Mircea

doi:10.1016/j.ejmech.2009.12.015

Cited by 89 publications

(43 citation statements)

References 44 publications

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“…The tiosemicarbazone HL was synthesized by refluxing equimolar amounts of thiosemicarbazide and β-cyclocetol in methanol according to the experimental protocol described in [28] (Scheme 1). The structure of the ligand was established by IR, 1 H-NMR, 13 C-NMR and mass spectroscopy data.…”

Section: Chemistrymentioning

confidence: 99%

“…In a previous paper [28] we presented the synthesis of Cu(II) and Pd(II) complexes with 8-propyl-2-hydroxytricyclo(7.3.1.0 2,7 )tridecan-13-one-thiosemicarbazone and 8-furyl-2-hydroxytricyclo(7.3.1.0 2,7 ) tridecan-13-one-thiosemicarbazone. This paper is a continuation of our previous research and it presents the synthesis and characterization of complexes of Cu(II), Pd(II) and Pt(II) with the new ligand 8-ethyl-2-hydroxytricyclo(7.3.1.0 2,7 )tridecan-13-one-thiosemicarbazone, a less voluminous substituent.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

et al. 2016

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New Cu(II), Pd(II) and Pt(II) complexes, (Cu(L)(H 2 O) 2 (OAc)) ( 1 ), (Cu(HL)(H 2 O) 2 (SO 4 )) ( 2 ), (Cu(L)(H 2 O) 2 (NO 3 )) ( 3 ), (Cu(L)(H 2 O) 2 (ClO 4 )) ( 4 ), (Cu(L) 2 (H 2 O) 2 ) ( 5 ), (Pd(L)(OAc))H 2 O ( 6 ), and (Pt(L) 2 ) ( 7 ) were synthesized from 8-ethyl-2-hydroxytricyclo(7.3.1.0 2,7 )tridecan-13-one thiosemicarbazone ( HL ). The ligand and its metal complexes were characterized by IR, 1 H-NMR, 13 C-NMR, UV-Vis, FAB, EPR, mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The free ligand and the metal complexes have been tested for their antimicrobial activity against E. coli , S. enteritidis , S. aureus , E. faecalis, C. albicans and cytotoxicity against the NCI-H1573 lung adenocarcinoma, SKBR-3 human breast, MCF-7 human breast, A375 human melanoma and HL-60 human promyelocytic leukemia cell lines. Copper complex 2 exhibited the best antiproliferative activities against MCF-7 human breast cancer cells. A significant inhibition of malignant HL-60 cell growth was observed for copper complex 2 , palladium complex 6 and platinum complex 7 , with IC 50 values of 1.6 µM, 6.5 µM and 6.4 µM, respectively.

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Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

et al. 2016

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“…Moreover, metal complexes can exhibit biological activities more than free ligand [6]. Recently, thiosemicarbazones and their metal complexes have achieved importance due to their application in pharmaceutical chemistry and proved to be chemotherapeutic agents potentially useful for inhibiting the activities of cancer cells [25,26].…”

Section: Introductionmentioning

confidence: 99%

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Karaküçük‐İyidoğan

Tasdemir

Oruç‐Emre

et al. 2011

European Journal of Medicinal Chemistry

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a b s t r a c tA series of thiosemicarbazones and their platinum(II) and palladium(II) complexes have been synthesized. The chemical structures of ligands and their complexes were characterized by UVeVis, IR, 1 H NMR, 13 C NMR, MS spectra, elemental analysis and TGA. The antiviral and cytotoxic activities of all compounds have been tested. Results of broad antiviral evaluation showed that none of the compounds evaluated endowed with anti-DNA or -RNA virus activity at subtoxic concentrations except for the palladium complex 1b. This compound exhibited slightly selective inhibition against cytomegalovirus. The platinum complex 4a exhibited the best cytostatic activities against human cervix carcinoma. Ligands 2, 4 and 5 showed cytostatic potential. The palladium complexes were in general less cytostatic than the corresponding platinum complexes or unliganded congeners.

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“…In the spectra of the metal complexes, this band is shifted to shorter wavelengths (Table 3) which indicates the coordination of DMATP to the metal ions. [34,35] The tetra-coordinated complex [(DMATP)NiCl 2 ] exhibits an anomalous magnetic moment value of 1.48 BM at room temperature which is lower than the values reported for regular tetrahedral structures and could not be a pure diamagnetic square planar structure. Turco et al [36] studied the magnetic moments of some diamagnetic square planar Ni(II) complexes in solution using inert solvents.…”

Section: Spectral and Magnetic Characteristics Of Dmatp-metal Complmentioning

confidence: 74%

Metal complexes of chalcone analogue: Synthesis, characterization, DNA binding, molecular docking and antimicrobial evaluation

Atlam

El‐Nahass

Bakr

et al. 2017

Applied Organom Chemis

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A novel chalcone, namely 5-(4-(dimethylamino)phenyl)-1-(thiophen-2-yl)penta-2,4-dien-1-one, DMATP, and its complexes with nickel(II), vanadium(III), palladium(II) and platinum(II) metal ions were synthesized and characterized using a set of chemical and spectroscopic tools including elemental analysis, electrical conductance, magnetic susceptibility and spectral techniques. The interactions of the synthesized chalcone and its metal complexes with DNA were studied using steady-state absorption and emission techniques as well as viscosity and electrochemical measurements. The obtained results confirm DNA intercalation. Additionally, theoretical studies were performed for all the investigated compounds using DFT/B3LYP calculations. The optimized geometries are found to be in good agreement with the suggested experimental structures. The bond lengths, bond angles, chemical reactivity, energy components, binding energy and dipole moment were evaluated. Also, theoretical infrared intensities and thermodynamic parameters for all compounds were calculated. Molecular docking calculations show that the Ni(II) complex exhibits the highest DNA binding activity, which agrees well with the experimental results. Finally, the compounds were screened for antimicrobial activity using several microorganisms.

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Synthesis, characterization antibacterial and antiproliferative activity of novel Cu(II) and Pd(II) complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0.2,7]tridecane-13-one thiosemicarbazone

Cited by 89 publications

References 44 publications

Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Metal complexes of chalcone analogue: Synthesis, characterization, DNA binding, molecular docking and antimicrobial evaluation

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