Synthesis, characterization, antibacterial, anticancer, and density‐functional theory studies of nano‐metal (II) oxime complexes

Abstract

New nanophenolic oxime complexes of the type [M(κ 2 -Saly) 2 ] {where HSaly = salicyl-aldoxime; M = Co(1), Ni(2), Cu(3), Pd(4), Pt(5), Zn(6), Cd(7), and Hg(8)} were prepared and characterized by different spectroscopic methods. The surface morphology and the micrographs of the investigated complexes were checked by the scanning electron microscopy (SEM) and Xray diffraction (XRD) analysis. The results indicate the successful preparation of nanocomplexes with nanoparticles size. In addition, the antibacterial activity was studied against three different pathogenic bacteria, and the Pt(II) complex displayed the highest activity compared with free salicylaldoxime ligand and other complexes. Magnetic susceptibility and ultraviolet (UV)-visible spectroscopic measurements were used to deduce the geometry of the complexes, which was then validated by density functional theory (DFT) calculations. The in vitro antitumor activity was investigated by MTT assays against HepG-2 cell lines. The Zn(II) and Pt(II) complexes displayed good activity with IC 50 values at 17.31 ± 0.95 and 11.78 ± 0.54 μM, respectively. In contrast, the [Cu(Saly) 2 ] and [Ni(Saly) 2 ] complexes showed the lowest activity against tested cells.

A series of nanosized Cu(II) complexes based on sulfonamide azo dye ligands: An insight into complexes molecular structures, antimicrobial, antitumor and catalytic performance for oxidative dimerization of 2‐aminophenol

“…The presence of metal ions, which are more hypersensitive to microbial cells than the organic chelating agent, can be linked to the increased antimicrobial action upon chelate formation. [57,58] Additionally, the increased lipophilicity on complexation may be responsible for the metal chelates' enhanced effect. The coordinated metal ions may inhibit cellular enzyme activity, or they may catalyze harmful interactions between cellular components.…”

High performance supercapacitive behaviors of oximes in a poly(aniline-co-pyrrole) based conducting polymer structure

“…68,70 These compounds have been employed in many fields of science with many application areas such as catalysis, 71,72 nanoparticles, 73,74 electrochemical sensors, [75][76][77] anti-chemical warfare agents, 76,78 anti-cancer [79][80][81] and anti-bacterial treatments. [82][83][84] Despite the wide usage of oximes in different areas, any notable studies had been working on in the field of energy storage about their properties. Considering the studies in the literature on other synthesized organic ligands and inorganic metal complexes, it is obviously clear that oximes can produce new and different results in this field with their properties.…”