Synthesis, Characterization, Anticancer, Pharmacokinetic, and Docking Studies of Vanillin-Benzimidazole Derivatives as Aromatase Inhibitors

Malebari, Azizah M.; Nazreen, Syed; Elbehairi, Serag Eldin I.; Elhenawy, Ahmed A.; Abdelhamid, Antar A.; Alfarsi, Anas; Shati, Ali A.; Alqurashi, Esam A.; Alfaifi, Mohammad Y.; Akhtar, Mohammad Salman; Alam, Mohammad Mahboob

doi:10.1080/10406638.2023.2289486

Polycyclic Aromatic Compounds

2023

DOI: 10.1080/10406638.2023.2289486

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Synthesis, Characterization, Anticancer, Pharmacokinetic, and Docking Studies of Vanillin-Benzimidazole Derivatives as Aromatase Inhibitors

Azizah M. Malebari,

Syed Nazreen,

Serag Eldin I. Elbehairi

et al.

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2024

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Cited by 2 publications

References 49 publications

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Benzimidazole‐Containing Compounds as Anticancer Agents

Acar Çevik,

Işik,

Kaya

et al. 2024

ChemistrySelect

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Cancer is the second leading cause of death today and remains a threat to human health. The advent of multi‐drug resistance and adverse effects make the current first‐line anti‐cancer medicines inadequate, despite the fact that numerous efforts have been made in the field of cancer therapy and significant progress has been made in the diagnosis and treatment of cancer. Consequently, the development of novel anticancer drugs with high activity and minimal toxicity is imperative. The benzimidazole ring has attracted the attention of medicinal chemists due to its medicinal and pharmacological properties. The heterocyclic pharmacophore of benzimidazole is a crucial scaffold for developing pharmaceuticals and drugs. In this review, we summarized the recent progress of benzimidazole as a privileged scaffold for the discovery of anti‐cancer agents based on biological targets, such as VEGFR (Vascular Endothelial Growth Factor), PI3 K inhibitors (Phosphoinositide 3‐kinase), EGFR kinase inhibitors (Epidermal Growth Factor Receptor), PARPs (Poly ADP‐ribose polymerases), Tubulin Polymerization, HAT/HDAC (histone acetylase/histone deacetylase), SphK1 (Sphingosine kinase‐1 inhibitors), aromatase, carbonic anhydrase, and topoisomerase inhibitors. The last 5 years of literature have been reviewed and relevant studies have been summarized in this review.

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Benzimidazole‐Containing Compounds as Anticancer Agents

Acar Çevik,

Işik,

Kaya

et al. 2024

ChemistrySelect

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Zn(II) and Cd(II) complexes of dithiocarbamate ligands: synthesis, characterization, anticancer, and theoretical studies

Abdalrazaq,

Abu-Yamin,

Taher

et al. 2024

Journal of Sulfur Chemistry

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Synthesis, Characterization, Anticancer, Pharmacokinetic, and Docking Studies of Vanillin-Benzimidazole Derivatives as Aromatase Inhibitors

Cited by 2 publications

References 49 publications

Benzimidazole‐Containing Compounds as Anticancer Agents

Benzimidazole‐Containing Compounds as Anticancer Agents

Zn(II) and Cd(II) complexes of dithiocarbamate ligands: synthesis, characterization, anticancer, and theoretical studies

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