Synthesis, Characterization, Antimicrobial, DNA Cleavage and Fluorescent Activity of Metal ion(II) Coordinate with 2H-Chromene Azo novel ligand

Nafea, Huda M.; Kawaz, Ali Muayad Nafea Al

doi:10.26452/ijrps.v11i2.2116

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…At this point, the increase and consequent decrease in the relative percentage of eupatoriochromene stands out. Some chromenes can act in the defense of vegetative organs against natural predators or phytopathogens [8,[109][110][111][112]. In addition, eupatoriochromene may be related to the process of maturation and development of inflorescences.…”

Section: Discussionmentioning

confidence: 99%

Volatile Chemical Variation of Essential Oils and Their Correlation with Insects, Phenology, Ontogeny and Microclimate: Piper mollicomum Kunth, a Case of Study

Machado

Ramos

Defaveri

et al. 2022

Plants

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The aim of this study was to monitor the volatile chemical composition from leaves and reproductive organs of Piper mollicomum Kunth (PM), in its reproduction period, as well as register inflorescence visitors, microclimate and phenological information. The essential oils (EOs) obtained from the different fresh organs by hydrodistillation were identified and quantified by Gas Chromatography/Mass Spectrometry (GC/MS) and by GC coupled to a Flame Ionization Detector (GC/FID), respectively. The cercentage content of some volatiles present in reproductive organs, such as limonene, 1,8-cineole, linalool and eupatoriochromene, increased during the maturation period of the inflorescences, and decreased during the fruiting period, suggesting a defense/attraction activities. Furtermore, a biosynthetic dichotomy between 1,8-cineole (leaves) and linalool (reproductive organs) was recorded. A high frequency of bee visits was registered weekly, and some correlations showed a positive relationship between this variable and terpenes. Microclimate has an impact on this species’ phenological cycles and insect visiting behavior. All correlations between volatiles, insects, phenology and microclimate allowed us to present important data about the complex information network in PM. These results are extremely relevant for the understanding of the mechanisms of chemical–ecological plant–insect interactions in Piperaceae, a basal angiosperm.

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Section: Discussionmentioning

confidence: 99%

Volatile Chemical Variation of Essential Oils and Their Correlation with Insects, Phenology, Ontogeny and Microclimate: Piper mollicomum Kunth, a Case of Study

Machado

Ramos

Defaveri

et al. 2022

Plants

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Brasiliensic acid: in vitro cytotoxic and genotoxic, in vivo acute toxicity and in silico pharmacological prediction of a new promising molecule

Lemos,

Ọlọ́ba-Whẹ̀nù,

Olasupo

et al. 2023

Journal of Biomolecular Structure and Dynamics

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DFT and In-silico Investigations, along with In-vitro Antitumor and Antimicrobial Assessments of Pharmacological Molecules

Alsehli

Seth

El‐Gaby

et al. 2023

COS

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Background: Molecules, bearing an active methylene bridge, are deemed to be one of the most fruitful and remarkable precursors that have been incorporated in the synthetic strategy of an assortment of bioactive compounds. Objective: The reactive methylene derivatives have been endowed with multiple reactions, which target biological and medicinal applications and are resultant from their structural multiplicity and discrete reactivity. Methods: The present report endeavors to synthesize, characterize, and in-vitro evaluate several novel propanoic acid, coumarin, and pyrazole derivatives as antimicrobial and antiproliferative agents. The in-silico molecular docking, physicochemical, pharmacokinetic/ADMET, bioactivity, and drug likeness predictions were conducted for all the synthesized compounds. Results: The highest docking score is -9.9 and -8.3 kcal/mol respectively for compound 9 (azo-coumarin) and 13 (acrylic acid derivative) with the target proteins E. coli topoisomerase II, DNA gyrase subunit B and PI3K p110α domain, respectively. Moreover, this study predicts the synthesized molecules that may inhibit the novel COVID-19, obtained through virtual screenings only, where compounds 9, 13, 14, 17, and 19 came to the limelight with good docking scores i.e more than 8 Kcal/mol. Safety profiling of the most potent compound 9 was utilized against normal cell line and hemolytic effect on RBCs. Conclusion: The in-silico ADMET studies of the synthesized compounds revealed moderate to good drug likeness, high gastro intestinal (GI) absorption, inhibits the Cytochrome CYP2C19 and CYP2C9 and all the derivatives possess non-cancerous nature. The in-vitro screening demonstrated that several of the novel molecules are promising drug candidates. The density function theory (DFT) theoretical calculations were performed to calculate the energy levels of the FMOs and their energy gabs, dipole moment as well as the molecular electrostatic potential. Such parameters along with the physicochemical parameters could be good tool to confirm the biological activity.

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Synthesis, Characterization, Antimicrobial, DNA Cleavage and Fluorescent Activity of Metal ion(II) Coordinate with 2H-Chromene Azo novel ligand

Cited by 3 publications

References 32 publications

Volatile Chemical Variation of Essential Oils and Their Correlation with Insects, Phenology, Ontogeny and Microclimate: Piper mollicomum Kunth, a Case of Study

Volatile Chemical Variation of Essential Oils and Their Correlation with Insects, Phenology, Ontogeny and Microclimate: Piper mollicomum Kunth, a Case of Study

Brasiliensic acid: in vitro cytotoxic and genotoxic, in vivo acute toxicity and in silico pharmacological prediction of a new promising molecule

DFT and In-silico Investigations, along with In-vitro Antitumor and Antimicrobial Assessments of Pharmacological Molecules

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