Synthesis, Characterization, Biological Assay of New 5-(Pyridine-2-Yl)-1,3,4-Oxadiazol-2-Amine Derivatives and their Molecular Docking Studies

Abstract

This study introduces a novel class of titled compounds, that are produced through a reaction of picolinohydrazide with various unsymmetrical anhydrides. The confirmation of the successful syntheses is affirmed through a detailed characterization protocol including Proton-NMR, 13C-NMR, FTIR, and Mass spectral studies. The resulting products, 2 as well as 3(a-e), underwent successive evaluations to determine their antibacterial capabilities on S. aureus and E. coli, and antifungal evaluation in relation to Candida albicans. Assessment of antimicrobial activity using the disc diffusion method and reference compounds revealed good efficacy in most of these synthesized compounds, revealing some that had very approving results. Computational docking showed that all new compounds exhibit good interactions. This study highlights the power of 5-(pyridine-2-yl)-1,3,4-oxadiazolo alkanamides against both anti-microbial strains.