Synthesis, characterization, biological evaluation, BSA binding properties, density functional theory and molecular docking study of Schiff bases

Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety

“…Due to the fluorescence quenching mechanism tyrosinase by compound 6j being static, the Lineweaver-Burk equation was used to calculate the binding constant ( K a) and binding sites (n) as 2.89 × 10 4 M −1 and 1.24, respectively. Based on the value of n (1.24), indicates that the interaction binding site between compound 6j and tyrosinase is only one ( Joksimovic et al, 2021 ). The Lineweaver-Burk equation is as follows: …”

Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors

“…Schiff bases, namely, imines, are one class of the widely utilized organic compounds and have a wide variety of applications in many fields, including, analytical, organic, bioorganic, and medicinal chemistry. [32][33][34][35] These compounds have recently gained very high importance in the medical and pharmaceutical fields due to their wide range of biological activities, including anti-Alzheimer, anticancer, and antioxidant activities. [36,37] Thus, their derivatives have continuously been used to design and discover new bioactive molecules.…”