Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

Abstract

Cu(II), Co(II), Ni(II) and Zn(II) metal-organic hybrids of new tridentate (NOS donor) Schiff base ligand derived from 4-(thiophen-2-yl)but-3-en-2-one (TB) and 2-aminophenol (AP) were synthesized, characterized and their pharmacological activities were evaluated. Possible geometry of the hybrid derivatives and the chelating atoms were investigated on the source of elemental analysis, magnetic moment, molar conductivity, infrared, EPR, NMR, electronic and mass spectral studies. The results were consistent with a three coordination environment around the metal ion. Synthesized compounds were screened for in vitro antimicrobial activity against bacteria Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Staphylococcus saprophyticus and fungi Candida albicans. Hybrid derivatives showed improved antibacterial and antifungal activity compared with the ligand 2(-4-(thiophen-2-yl)but-3-en-2-ylidene amino)phenol (TBAP). DNA cleavage experiments done by means of gel electrophoresis with corresponding hybrid derivatives in the presence of H 2 O 2 showed pronounced discernible DNA cleavage.