Synthesis, characterization, crystal structure and biological activity of a novel heterotetranuclear complex: [NiLPb(SCN)(DMF)(HO)], bis-{[μ-,′-bis(salicylidene)-1,3-propanediaminato-aqua-nickel(II)](thiocyanato)(μ-thiocyanato)(μ-,′-dimethylformamide)lead(II)}

Kurtaran, Raıf; Yıldırım, Leyla Tatar; Azaz, Ayşe Dilek; Namlı, Hilmi; Atakol, Orhan

doi:10.1016/j.jinorgbio.2005.05.016

Cited by 102 publications

(17 citation statements)

References 21 publications

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“…For coupling in the [(2ÀH) 2 Cu 2 ClA C H T U N G T R E N N U N G (TMEDA) 2 ] + complex, this reaction mechanism is probably less efficient, but it becomes the major one when the coupling reaction is performed with copper(II) salts alone, that is, in the absence of TMEDA or other amine ligands which support clustering. [46] While our gas-phase studies cannot directly be translated to solution chemistry, the present findings still suggest some objectives for the design of naphthol coupling catalysts in applied synthesis. First, our results demonstrate that, at least in the case of the Cu I /Cu II redox system, formation of binuclear complexes facilitates the coupling process.…”

Section: Resultsmentioning

confidence: 85%

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by Cu^II⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Roithová

Schröder

2008

Chemistry A European J

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The mechanism of oxidative coupling of two naphthol molecules to form binaphthol catalyzed by Cu(OH)ClTMEDA (TMEDA=N,N,N',N'-tetramethylethylenediamine) was approached by means of a gas-phase model system. Concise evidence is provided that the coupling reaction proceeds in clusters with two Cu(II) centers, whereby the intermediacy of free naphthoxy radicals in the coupling step is avoided. In the absence of TMEDA, the cluster is bound via a bridging counterion and the coupling reaction is followed by cluster cleavage. The coordination of one or two TMEDA molecules to the reactive complex results in more efficient coupling of naphthol molecules, and moreover, the binuclear cluster is also conserved after the reaction is completed. The effect of TMEDA is twofold: First, it supports clustering of copper and, second, as a ligand bound to a copper center in the reactive complex, it weakens the bond between copper and the naphtholato ligand such that the naphtholato unit is more prone to undergo C--C coupling. Furthermore, a pronounced counterion effect is found that correlates well with condensed-phase data: weakly bridging counterions (e.g., NO3(-)) yield less stable dicopper clusters and the coupling reaction hardly occurs, whereas better bridging counterions (e.g., Cl(-) or Br(-)) provide more stable clusters that make the coupling reaction more efficient.

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Section: Resultsmentioning

confidence: 85%

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by Cu^II⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Roithová

Schröder

2008

Chemistry A European J

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“…Nickel is recognized as an essential trace element because several hydrogenases and carbon monoxide dehydrogenases [ 13 ] contain nickel ions in the active site. More specifically, nickel complexes with varied biological activities have been reported in the literature, for instance, with antibacterial [ 14 , 15 , 16 ], antifungal [ 15 ] and antiproliferative/anticancer properties [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies

Zhang

et al. 2017

Molecules

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In this study, two Ni(II) complexes, namely [Ni(HL1)2(OAc)2] (1) and [Ni(L2)2] (2) (where HL1 and HL2 are (E)-1-((1-(2-hydroxyethyl)-1H-pyrazol-5-ylimino)methyl)-naphthalen-2-ol) and (E)-ethyl-5-((2-hydroxynaphthalen-1-yl)methyleneamino)-1-methyl-1H-pyrazole-4-carboxylate, respectively), were synthesized and characterized by X-ray crystallography, Electrospray Ionization Mass Spectrometry (ESI-MS), elemental analysis, and IR. Their uptake in biological macromolecules and cancer cells were preliminarily investigated through electronic absorption (UV-Vis), circular dichroism (CD) and fluorescence quenching measurements. Bovine serum albumin (BSA) interaction experiments were investigated by spectroscopy which showed that the complexes and ligands could quench the intrinsic fluorescence of BSA through an obvious static quenching process. The spectroscopic studies indicated that these complexes could bind to DNA via groove, non-covalent, and electrostatic interactions. Furthermore, in vitro methyl thiazolyl tetrazolium (MTT) assays and Annexin V/PI flow cytometry experiments were performed to assess the antitumor capacity of the complexes against eight cell lines. The results show that both of the complexes possess reasonable cytotoxicities.

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“…Herein we report a new tetranuclear Pb(II) coordination cage synthesized with the 4-nitrobenzoic acid introduced into the system of Pb II /8-hydroxyquinoline. In recent years, a few Pb(II) complexes have been reported concerning their biological activities, such as DNA binding property (Gao et al, 2017;Li et al, 2008;Shen et al, 2016;Zhang et al, 2015), anticancer (Abd-Elzaher et al, 2012;Ghosh et al, 2017) and antimicrobial (El-Megharbel et al, 2014;Kurtaran et al, 2005;Pallikkavil et al, 2013;Ravichandran et al, 2014;Singh et al, 2010) activity. In this paper, in addition to the complex was characterized by elemental analysis, IR spectroscopy, and X-ray singlecrystal diffraction, as an attempt, the interaction between the complex, [Pb(8-OQ)(4-NB)], and DNA was investigated by UV absorption and fluorescence spectra, anticancer activity against MCF-7, HepG-2 and A549 cell lines of the complex was also tested by the MTT-based assay.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure, DNA binding and anticancer activity of a new tetranuclear Pb(II) complex constructed by 8-hydroxyquinolinate and 4-nitrobenzoate ligands

Liu

Xia

Cheng

et al. 2019

Main Group Metal Chemistry

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A new Pb(II) complex, [Pb(8-OQ)(4-NB)], where 8-OQ = 8-hydroxyquinolinate, 4-NB = 4-nitrobenzoate, has been synthesized and characterized by elemental analysis, IR spectroscopy, and X-ray single-crystal diffraction. The single crystal X-ray analysis reveals that the complex possesses a tetranuclear Pb4O4 cubane structure. The Pb(II) atom is coordinated by three triply bridging phenolic hydroxyl O atoms of 8-OQ ligands, then the tetranuclear Pb system is formed resulting in a tetrahedral cage. The interaction of complex with HS-DNA in Tris buffer was studied by UV−vis absorption spectrum and fluorescence ethidium bromide displacement experiment with an intrinsic binding constant of 1.52×104 M-1 and a linear Stern–Volmer quenching constant of 6.77×103 M-1. Anticancer activity against MCF-7, HepG-2 and A549 cell lines of complex was also determined by the MTT-based assay. The results showed the complex can inhibit proliferation of these three kinds of tumor cells and is less cytotoxic than cisplatin.

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Synthesis, characterization, crystal structure and biological activity of a novel heterotetranuclear complex: [NiLPb(SCN)(DMF)(HO)], bis-{[μ-,′-bis(salicylidene)-1,3-propanediaminato-aqua-nickel(II)](thiocyanato)(μ-thiocyanato)(μ-,′-dimethylformamide)lead(II)}

Cited by 102 publications

References 21 publications

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by Cu^II⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by Cu^II⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies

Synthesis, structure, DNA binding and anticancer activity of a new tetranuclear Pb(II) complex constructed by 8-hydroxyquinolinate and 4-nitrobenzoate ligands

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Synthesis, characterization, crystal structure and biological activity of a novel heterotetranuclear complex: [NiLPb(SCN)(DMF)(HO)], bis-{[μ-,′-bis(salicylidene)-1,3-propanediaminato-aqua-nickel(II)](thiocyanato)(μ-thiocyanato)(μ-,′-dimethylformamide)lead(II)}

Cited by 102 publications

References 21 publications

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by CuII⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by CuII⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies

Synthesis, structure, DNA binding and anticancer activity of a new tetranuclear Pb(II) complex constructed by 8-hydroxyquinolinate and 4-nitrobenzoate ligands

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Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by Cu^II⋅TMEDA: Evidence for the Key Role of Binuclear Clusters

Gas‐Phase Study on the CC Coupling of Naphthol Catalyzed by Cu^II⋅TMEDA: Evidence for the Key Role of Binuclear Clusters