Synthesis, characterization, crystal structure, and fluorescence behavior of new 4-aryl-6-(2,5-dichlorothiophen-3-yl)-2-methylpyridine-3-carbonitrile derivatives

Synthesis, characterization, antibacterial activity and cytotoxicity of (1′R,2′S,7a′S)‐2′‐(2,5‐dichlorothiophene‐3‐carbonyl)‐1′‐(aryl)‐1′,2′,5′,6′,7′,7a′‐hexahydrospiro[indoline‐3,3′‐pyrrolizin]‐2‐one derivatives

“…Additional studies of the synthesis of a diverse substituted spirooxindoles via 1,3‐dipolar cycloaddition reaction are reported [12–17]. In continuation to our work [18–24], we herein report the synthesis and characterization of (1′R,2′S,7a′S)‐2′‐(2,5‐dichlorothiophene‐3‐carbonyl)‐1′‐(aryl)‐1′,2′,5′,6′,7′,7a′‐hexahydrospiro[indoline‐3,3′‐pyrrolizin]‐2‐one, I , derivatives by the reaction of the corresponding 2,5‐dichlorothiophene containing chalcone (2,5‐dichlorothiophene has not been explored extensively), l ‐proline and 2,3‐indolinedione. The molecular, crystal structure and crystal supramolecularity of three derivatives, namely, (1′R,2′S,7a′S)‐1′‐(4‐(tert‐butyl)phenyl)‐2′‐(2,5‐dichlorothiophene‐3‐carbonyl)‐1′,2′,5′,6′,7′,7a′‐hexahydrospiro[indoline‐3,3′‐pyrrolizin]‐2‐one, (1′R,2′S,7a′S)‐2′‐(2,5‐dichlorothiophene‐3‐carbonyl)‐1′‐(4‐fluorophenyl)‐1′,2′,5′,6′,7′,7a′‐hexahydrospiro[indoline‐3,3′‐pyrrolizin]‐2‐one and (1′R,2′S,7a′S)‐1′‐(3‐Chlorophenyl)‐2′‐(2,5‐dichlorothiophene‐3‐carbonyl)‐1′,2′,5′,6′,7′,7a′‐hexahydrospiro[indoline‐3,3′‐pyrrolizin]‐2‐one are also reported.…”