Synthesis, characterization, cytotoxic activity and crystal structures of tri- and di-organotin(IV) complexes constructed from the β-{[(E)-1-(2-hydroxyaryl)alkylidene]amino}propionate and β-{[(2Z)-(3-hydroxy-1-methyl-2-butenylidene)]amino}propionate skeletons

Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization, and in vitro cytotoxicity studies

“…in CDCl 3 exhibit a single sharp 119 Sn resonance in the range -83 to -103 ppm, suggesting that the Sn-atoms in the complexes have the same four-coordinate environment [42,47,49,62,63]. This is also reflected in 1 J( 13 C-119/117 Sn) coupling constants (see experimental) and the values are unambiguously characteristic for four-coordinate tin atoms [63].…”

“…In view of the increasing interest in organotin(IV) carboxylates and prompted by their structural diversity [38] and broad therapeutic activity [27], organotin(IV) complexes of Schiff bases derived from amino acids have also been investigated extensively [39][40][41][42][43][44][45][46][47][48][49]. An overview of the coordination behaviour of such Schiff bases towards organotin(IV) is shown in Scheme 1.…”

“…An overview of the coordination behaviour of such Schiff bases towards organotin(IV) is shown in Scheme 1. Some of these organotin(IV) compounds were screened for antitumour activity in vivo in Ehrlich ascites carcinoma cells [41] and cytotoxic activity in vitro against cell lines of human origin [47,49] …”

Heptacoordinate Tin(IV) Compounds Derived from Pyridine Schiff Bases: Synthesis, Characterization, in Vitro Cytotoxicity, Anti-inflammatory and Antioxidant Activity

“…21,22) The Schiff base-organotin complexes have received special attention in view of their chemistry and structural aspects of hypervalent species. [23][24][25][26][27][28][29][30] Regarding this, investigations concerning chelating properties and coordinative effects of 2,6-diacetylpyridine and its influence on the conformation and geometry of heptacoordinated tin complexes derived of hydrazones, 31,32) semicarbazones, thiosemicarbazones, [33][34][35][36][37][38][39][40] acylhydrazones, 41) have been undertaken. Our interest in organotin(IV) and organosilicon compounds containing pyridine moieties let us to study the influence and nature of the ligand substituents in the formation of pentacoordinate tin and silicon derivatives.…”

Synthesis and Characterization of Some Triphenyltin(IV) Complexes from Sterically Crowded [((E)-1-{2-Hydroxy-5-[(E)-2-(aryl)-1-diazenyl]phenyl}methylidene)amino]acetate Ligands and Crystal Structure Analysis of a Tetrameric Triphenyltin(IV) Compound

“…The construction of multidimensional architectures depends on the combination of several factors including the type of organic ligands, tin-R groups, tin coordination geometry preferences and metal-to-ligand molar ratio. The self-assembly of organotin(IV) complexed Schiff bases containing the amino acetate moiety is particularly attractive, since it can be accomplished in one-pot reactions, and the complexes have attracted much interest owing to their novel structural possibilities and therapeutic activity [3][4][5][6][7][8][9][10][11][12][13][14]. Recent reports on the structures of such complexes [3][4][5][6][7][8][9][10][11][12][13][14] show that Schiff base-amino acid systems are …”