2018
DOI: 10.1002/aoc.4312
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Synthesis, characterization, density functional theory, X‐ray study, thermal stability, and biological and MOE relevance of metal complexes of griseofulvin

Abstract: Metal(II) and metal(III) coordination compounds of griseofulvin (GFV) drug were synthesized. The structure of the ligand was determined on the basis of elemental analyses, infrared and 1 H NMR spectroscopies and thermal studies.GFV behaved as a neutral tridentate chelating agent and coordinated to metal ions through three oxygen atoms: two methoxy groups and oxygen atom of furan ring. Metal complexes were characterized by means of elemental analyses and molar conductance, spectral (infrared, electron spin reso… Show more

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Cited by 3 publications
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“…40 For the docking study, Molecular Operating environment (MOE 2008.10, Chemical Computing Group Inc. Quebec, Canada) was used. 41 The ligands were built by using the builder tool of the MOE program and were subjected to energy minimization (MMFF94x, gradient: 0.05). 42 The crystal structure of FAK catalytic domain (PDB:4K9Y) was imported from PDB.…”
Section: Molecular Modeling Studymentioning
confidence: 99%
“…40 For the docking study, Molecular Operating environment (MOE 2008.10, Chemical Computing Group Inc. Quebec, Canada) was used. 41 The ligands were built by using the builder tool of the MOE program and were subjected to energy minimization (MMFF94x, gradient: 0.05). 42 The crystal structure of FAK catalytic domain (PDB:4K9Y) was imported from PDB.…”
Section: Molecular Modeling Studymentioning
confidence: 99%