Synthesis, characterization, DFT calculation, DNA binding and antimicrobial activities of metal complexes of dimedone arylhydrazone

Abou‐Melha, Khlood S.; Al‐Hazmi, Gamil A.A.; Althagafi, Ismail; Alharbi, Arwa; Shaaban, Fathy; El‐Metwaly, Nashwa M.; El-Bindary, A.A.; El‐Bindary, Mohamed A.

doi:10.1016/j.molliq.2021.116498

Cited by 63 publications

(37 citation statements)

References 53 publications

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“…[3] Additionally, the metal chelates of hydrazones have gained attention due to their biological activity and ability to act as inhibitors for many enzymes. [4][5][6] Many hydrazones have analytical uses, such as metal extraction agents and sensors. [7] Hydrazones have a number of places of interaction and able to bind with transition metals in both keto and enol forms.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

El‐Bindary

El-Bindary

2022

Applied Organom Chemis

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A chain of metal(II) chelates that M = Co2+, Ni2+, and Cu2+ have been produced from 2‐(4‐sulfadiazine)hydrazono dimedone (HL) and characterized on analyses of elemental, Fourier‐transform infrared (FTIR) spectra, electronic, susceptibility to magnetic fields, and molar conductance. The chelates are nonelectrolytes, according to measurements of conductance. Spectroscopy methods and additional analytical measurements detect pseudo octahedral shape of Co2+ and Ni2+ chelates, but square planar structure for Cu2+ chelate. The ligand (HL) acts as a monobasic bidentate ligand by coordinating via oxygen atom of the carbonyl (C═O) group and the nitrogen atom of the hydrazone moiety (NH) with deprotonation. The enhanced, bond angles, bond lengths, and quantum chemical factors were used to determine the ligand and its complexes. Absorption spectra method and measurements of viscosity were used to investigate DNA linking activity. In the viability experiment of vinblastine and colchicine, the findings of synthesized compounds against the human cancer cell lines MCF‐7 and HepG‐2 were reported in contrast to positive controls. The antioxidant function of chelates is resolute by means of the free radical‐scavenging analyze (DPPH). As a final point, the antimicrobial effects of the chelates were studied utilizing the diffusion disc technique on fungal (Candida albicans), gram‐positive (Staphylococcus aureus), and gram‐negative (Escherichia coli) bacteria.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

El‐Bindary

El-Bindary

2022

Applied Organom Chemis

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“…The results are shown in Table 13. The results clarified that uranyl complexes show better anticancer activities than ligands when both cells are examined [54][55][56][57][58][59].…”

Section: Anticancer and Toxicological Studiesmentioning

confidence: 81%

“…The results are shown in Table 13. The results clarified that uranyl complexes show better anticancer activities than ligands when both cells are examined [54][55][56][57][58][59]. By comparison with the literature results [8][9][10][11][12] of the activity of uranyl complexes as anticancer agents for many different cell lines, it was found that the Schiff's base uranyl complexes that were prepared in this study have more effective IC50, which indicated less toxicity than previously reported results, which may be because this is the first study that investigated their effect against ovarian cancer and melanoma cell lines.…”

Section: Anticancer and Toxicological Studiesmentioning

confidence: 86%

Synthesis, Structural Investigations, Molecular Docking, and Anticancer Activity of Some Novel Schiff Bases and Their Uranyl Complexes

et al. 2021

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Three novel 2-aminopyrazine Schiff bases derived from salicylaldehyde derivatives and their uranyl complexes were synthesized and characterized by elemental analysis, UV-vis, FTIR, molar conductance, and thermal gravimetric analysis (TGA). The proposed structures were optimized using density functional theory (DFT/B3LYP) and 6–311G ∗(d,p) basis sets. All uranyl complexes are soluble in DMSO and have low molar conductance, which indicates that all the complexes are nonelectrolytes. The DNA binding of those Schiff bases and their uranyl complexes was studied using UV-vis spectroscopy, and screening of their ability to bind to calf thymus DNA (CT-DNA) showed that the complexes interact with CT-DNA through an intercalation mode, for which the Kb values ranged from 1 × 106 to 3.33 × 105 M−1. The anticancer activities of the Schiff base ligands and their uranyl complexes against two ovarian (Ovcar-3) and melanoma cell lines (M14) were investigated, and the results indicated that uranyl complexes exhibit better results than the Schiff base ligands. Molecular docking identified the distance, energy account, type, and position of links contributing to the interactions between these complexes and two different cancer proteins (3W2S and 2OPZ).

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“…On the other hand, amines are efficient organic compounds that are widely used for the formation of agrochemicals, dyes, pigments, polymers, and pharmaceuticals. [58][59][60][61][62] Moreover, electrochemical, photochemical, and sensing features of the amine-containing phthalocyanines are improved during the alteration of the energy levels of phthalocyanine rings. [63][64][65] The design of multidisciplinary materials for biological and medicinal applications is the most important purpose of this study.…”

Section: Introductionmentioning

confidence: 99%

The design and synthesis of metallophthalocyanine–gold nanoparticle hybrids as biological agents

et al. 2022

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Synthesis, characterization, DFT calculation, DNA binding and antimicrobial activities of metal complexes of dimedone arylhydrazone

Cited by 63 publications

References 53 publications

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

Synthesis, Structural Investigations, Molecular Docking, and Anticancer Activity of Some Novel Schiff Bases and Their Uranyl Complexes

The design and synthesis of metallophthalocyanine–gold nanoparticle hybrids as biological agents

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