Synthesis, characterization, DFT calculations and antibacterial activity of palladium(II) cyanide complexes with thioamides

Ahmad, Saeed; Nadeem, Shafqat; Anwar, Aneela; Hameed, Abdul; Tirmizi, Syed Ahmed; Zierkiewicz, Wiktor; Abbas, Ali; Isab, Anvarhusein A.; Alotaibi, Mshari A.

doi:10.1016/j.molstruc.2017.03.098

Cited by 15 publications

(4 citation statements)

References 35 publications

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“…The H-bond parameters are mentioned in Table 3. These values are close to those reported for other similar complexes [17,34,[46][47][48][49] [17,47]. The N-H bending vibration was detected near 1500 cm -1 .…”

Section: X-ray Structure Studiessupporting

confidence: 89%

2D polymeric cadmium(II) complexes containing 1,3-imidazolidine-2-thione (Imt) ligand, [Cd(Imt)(H 2 O) 2 (SO 4 )] n and [Cd(Imt) 2 (N 3 ) 2 ] n

Mahmood

Ahmad

Fettouhi

et al. 2018

Journal of Molecular Structure

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Section: X-ray Structure Studiessupporting

confidence: 89%

2D polymeric cadmium(II) complexes containing 1,3-imidazolidine-2-thione (Imt) ligand, [Cd(Imt)(H 2 O) 2 (SO 4 )] n and [Cd(Imt) 2 (N 3 ) 2 ] n

Mahmood

Ahmad

Fettouhi

et al. 2018

Journal of Molecular Structure

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“…The fact that the theoretical spectrum was made Pt(II) ion is located in the center of a slightly distorted square planar coordination geometry. The Pt-Cl (2.41 Å), Pt-S (2.45 Å) and Pt-N ammonia (2.09 Å) bond lengths are similar or close to values observed for other optimized square planar complexes [31][32][33][34][35]. After coordination of the ligand with the platinum ion, the ligand geometry will not change significantly, according to the theoretical analysis.…”

Section: Quantum Chemical Modelingsupporting

confidence: 81%

3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity

et al. 2022

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Herein, we report the synthesis of platinum(II) complex bearing 3′-aminothiocyclohexanespiro-5′-hydantoin as ligand. The complex was characterized by IR, NMR spectral analyses, elemental analyses and density functional theory (DFT) calculations. Cytotoxicity and inhibitory potential on xanthine oxidase (XO) were evaluated by performed docking calculations. The cytotoxic activities of the 3′-aminothiocyclohexanespiro-5′-hydantoin (1), its Pt(II) complex (2), thiocyclohexanespiro-5′-hydantoin (3), and its platinum complex (4) were assessed against HL-60 and MDA-MB-231 cells in comparison with the antiproliferative activity of cisplatin as a referent. The ligands (1 and 3) did not exhibit in vitro antitumor efficacy on either of the human tumor cell lines. Complex 2 showed higher antitumor activity (IC50 = 42.1 ± 2.8 µM on HL-60 and 97.8 ± 7.5 µM against MDA-MB-231 cells) than complex 4 (IC50 = 89.6 ± 2.8 µM on HL-60 and 112.5 ± 4.2 µM in MDA-MB-231 cells). IC50 values of cisplatin as referent were 8.7 ± 2.4 µM on HL-60 and 31.6 ± 5.4 µM on MDA-MB-231 cell lines. The inhibitory activity of ligands and complexes against XO, evaluated in vitro, were compared with allopurinol (IC50 = 1.70 ± 0.51 μM) as standard inhibitor. The platinum(II) complexes (2 and 4) inhibited the activity of XO, with IC50 values 110.33 ± 26.38 μM and 115.45 ± 42.43 μM, respectively, while the ligands 1 and 3 did not show higher degrees of inhibition at concentrations lower than 150 µM. The inhibitory potential against XO might be a possible precedent resulting in improved profile and anticancer properties.

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“…The Pd-S bond lengths are similar to those found in the literature for other optimized Pd complexes. [9][10] The Pd-Cl bond lengths are slightly shorter in Pd(II) than in Pd(IV). One of the valence angles of Pd-S-C is increased by 6.9 o in the Pd(IV) complex while another one is decreased by 5 o .…”

Section: Resultsmentioning

confidence: 98%

Palladium complexes with 3-methyl-8-thia-1,3-diaza- spiro[4.5]decane-2,4-dione: experimental and theoretical studies

Cherneva¹,

Buyukliev²,

Bakalova³

2018

Arkivoc

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Platinum complexes are a cornerstone of the treatment of various cancers. Their side effects, however, like nephrotoxicity and ototoxicity, have led to the investigation of alternative metal-based anticancer drugs such as palladium complexes, which show promising activities. New cis-palladium complexes with general formulas [PdL 2 Cl 2 ] and [PdL 2 Cl 4 ] and ligand 3-methyl-8-thia-1,3-diaza-spiro[4.5]decane-2,4-dione have been synthesized. The structures of the complexes were elucidated by elemental analyses and spectroscopic techniques as well as theoretical methods. Quantum chemical calculations confirm the square planar geometry of Pd(II) and a distorted octahedral coordination of Pd(IV) complexes. The in vitro cytotoxicity-assay results against K-562 and REH cell lines are also reported.

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Synthesis, characterization, DFT calculations and antibacterial activity of palladium(II) cyanide complexes with thioamides

Cited by 15 publications

References 35 publications

2D polymeric cadmium(II) complexes containing 1,3-imidazolidine-2-thione (Imt) ligand, [Cd(Imt)(H 2 O) 2 (SO 4 )] n and [Cd(Imt) 2 (N 3 ) 2 ] n

2D polymeric cadmium(II) complexes containing 1,3-imidazolidine-2-thione (Imt) ligand, [Cd(Imt)(H 2 O) 2 (SO 4 )] n and [Cd(Imt) 2 (N 3 ) 2 ] n

3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity

Palladium complexes with 3-methyl-8-thia-1,3-diaza- spiro[4.5]decane-2,4-dione: experimental and theoretical studies

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