Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α‐Diimine and Quinoxaline Ligands

Abstract

The complex [ReOCl3pq] (1) (where pq = 2-(2′pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl3bpy] (2), [ReOCl3phen] (3), and pq (4) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated.

Necroptosis-Inducing Rhenium(V) Oxo Complexes

“…ReOCl 3 (PPh 3 ) 2 was prepared as previously reported. 78 The synthesis of 1 has been reported previously, 79 but the procedure reported here is novel. Analytical grade acetone and dichloromethane were used as solvents.…”

A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?

“…The corresponding bidentate ligand has been chosen owing to the remarkable biological properties reported [125, 126], while, on the other hand, investigation of the biological activity of inert metal complexes, such as rhodium(III) compounds, shows gradually increasing interest [127–130]. These reasons led us to design the target molecule Rh-1 (Figure 4) with octahedral coordination geometry and evaluate in vitro its inhibitory effect against PAF-induced platelet aggregation in washed rabbit platelets (WRPs).…”

“…In 2009, we have successfully reported a preliminary work [ 124 ] on the anti-PAF activity of a Rh(III) coordination compound, namely, cis-[Rh(L) 2 Cl 2 ]Cl ( Rh-1 ), where L stands for the bidentate ligand 2,2′-pyridylquinoxaline with an IC 50 value of 250 nM ( Figure 4 ). The corresponding bidentate ligand has been chosen owing to the remarkable biological properties reported [ 125 , 126 ], while, on the other hand, investigation of the biological activity of inert metal complexes, such as rhodium(III) compounds, shows gradually increasing interest [ 127 – 130 ]. These reasons led us to design the target molecule Rh-1 ( Figure 4 ) with octahedral coordination geometry and evaluate in vitro its inhibitory effect against PAF-induced platelet aggregation in washed rabbit platelets (WRPs).…”

Synthesis, DNA-Binding, Anticancer Evaluation, and Molecular Docking Studies of Bishomoleptic and Trisheteroleptic Ru-Diimine Complexes Bearing 2-(2-Pyridyl)-quinoxaline

“…When coordinated to metal ions, the resulting complexes have interesting bioinorganic applications. For example, [ReOCl 3 (2, 2′-pq)] can efficiently cleave plasmid pBR 322DNA upon irradiation by generating singlet oxygen and hydroxyl radicals [18]. Furthermore, incorporation of 2, 2′pq in Pt-diamine complexes [19] and study against murine leukemia results in IC 50 values in the range of ∼40 μM.…”