Synthesis, characterization, DNA binding, DFT, anticancer, antibacterial, and the effect of gamma irradiation of novel Co(II), Ag (I), and Cd (II) complexes with hydrazone derivatives

Abdalla, Ehab M.; Al-Sulami, Ahlam I.; Aly, Samar A.; Abd-Allah, M.T.; Nasr, Ghada M.; Albohy, Salwa A.H.; Hosny, Shimaa

doi:10.1016/j.jscs.2023.101770

Cited by 10 publications

(1 citation statement)

References 62 publications

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“…56,57 The bands reported at 1690 cm À1 and 1280 cm À1 were associated with the uncoordinated (n(CQO) and n(C-O)) in the BDC, respectively. [58][59][60][61][62] After coordination, these absorption bands were replaced by the n(COO À ) of carboxylates, and their absorption bands were shifted to n as (COO À ) at ca. 1598 and 1533 cm À1 , and n s (COO À ) at ca.…”

Section: Structure Characterizationmentioning

confidence: 99%

A facile sonochemical synthesis of the Zn-based metal–organic framework for electrochemical sensing of paracetamol

Ismail,

Hassan,

Medany

et al. 2024

Mater. Adv.

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Section: Structure Characterizationmentioning

confidence: 99%

A facile sonochemical synthesis of the Zn-based metal–organic framework for electrochemical sensing of paracetamol

Ismail,

Hassan,

Medany

et al. 2024

Mater. Adv.

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Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Al Motwaa,

Al‐Otaibi,

Abubakr

et al. 2024

Applied Organom Chemis

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Oxovanadium (IV) and diphenyltin (IV) complexes were synthesized on the nanoscale based on the Schiff base (H2L) derived from salicylaldehyde and d‐glucosamine. The complexes were formed with a molar ratio of 1:1 and 1:2 (metal: dligand) relative to oxovanadium (IV) and diphenyltin (IV), respectively. Fourier‐transform infrared spectroscopy, 1H and 13C nuclear magnetic resonance, mass fragmentations, electronic transitions, thermogravimetric analysis, and density functional theory were employed to validate the structure of synthesized compounds. The results demonstrated that the ligand (H2L) was successfully attached to oxovanadium (IV) and diphenyltin (IV) as di‐anionic and mono‐anionic ligands, respectively. The size of the complexes was investigated using the transmission scanning microscope. The work presents a prospective concept for the drug design of the targeted anticancer through the glucose moiety. All compounds revealed remarkable anticancer activities against the colorectal (HCT‐116) cell line, recording IC50 values 4.94, 21.73, and 62.5 μg/ml for VO (II)(L), free H2L, and Sn (ph)2(HL)2, respectively. The IC50 value of VO (II)(L) complex was increased after the quercetin inhibitor. Therefore, the sugar‐conjugated compound can be recognized by the glucose recognition binding site of GLUT and their cell‐killing effect depends highly on the GLUT inhibitor, quercetin. The potential GLUT transportability of the compounds was investigated through a molecular docking study. The anti‐migration activity was investigated for VO (II)(L) complex. The free ligand observed the best antimicrobial results. The antibacterial stimulation was investigated and represented different interaction types with the selected ribosyl transferase enzyme.

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Synthesis, characterization, anticancer, antibacterial, antioxidant, DFT, and molecular docking of novel La (III), Ce (III), Nd (III), and Dy (III) lanthanide complexes with Schiff base derived from 2‐aminobenzothiazole and coumarin

Abo‐Rehab,

Kasim,

Farhan

et al. 2024

Applied Organom Chemis

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Four novel lanthanide La (III), Ce (III), Nd (III), and Dy (III) complexes with (Z)‐4‐(benzo[d]thiazol‐2‐ylamino)‐3‐((benzo[d]thiazol‐2‐ylimino)methyl)‐2H‐chromen‐2‐one (L) were prepared and characterized. The novel compounds' structural compositions were elucidated by the application of analytical and spectroscopic methodologies. From physical and chemical measurements, the general formula for the [LnLCl3]2H2O complexes (C1‐C4) was proposed, which was proven by theoretical measurements. Using cisplatin, gentamicin, ampicillin, and ascorbic acid as standards, the compound's anticancer, antibacterial, and antioxidant qualities were assessed, and activities followed the order: Ce (III)L(C2) > Nd (III)L(C3) > Dy (III)L(C4) > La (III)L(C1) > L where the Ce (III) complexes exhibited the highest activity followed by Nd (III) complexes. Molecular docking studies were performed using the MOA2022 software to identify putative binding mechanisms for the methionine adenosyl‐transferases in liver cancer (PDB ID: 5A19) and the most active site of the Bacillus subtilis receptor (PDB ID: 5e6k), where the strength of the interaction increases with the negative binding energy L ˂ [LaLCl3] ˂ [DyLCl3] ˂ [NdLCl3] ˂ [CeLCl3].

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Synthesis, characterization, DNA binding, DFT, anticancer, antibacterial, and the effect of gamma irradiation of novel Co(II), Ag (I), and Cd (II) complexes with hydrazone derivatives

Cited by 10 publications

References 62 publications

A facile sonochemical synthesis of the Zn-based metal–organic framework for electrochemical sensing of paracetamol

A facile sonochemical synthesis of the Zn-based metal–organic framework for electrochemical sensing of paracetamol

Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

Synthesis, characterization, anticancer, antibacterial, antioxidant, DFT, and molecular docking of novel La (III), Ce (III), Nd (III), and Dy (III) lanthanide complexes with Schiff base derived from 2‐aminobenzothiazole and coumarin

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