Synthesis, Characterization, Electrochemical Behaviour, DNA Binding and Cleavage Studies of Substituted β-DiketimineCopper(II) and Zinc(II) Complexes

Abstract

Several novel copper(II) and zinc(II) complexes have been synthesized from Schiff base(s) obtained by the condensation of Knoevenagel condensate, 3-(3-phenyl-allylidene)-pentane-2,4-dione with p-substituted (X) aniline where X = -NO 2 (L 1 ), -H (L 2 ), -OH (L 3 ) and -OCH 3 (L 4 )] and, copper(II) chloride/zinc(II) chloride. They have been characterized by analytical and spectral techniques. Electronic absorption and electrochemicalmeasurements prove that the complexes intercalate into DNA. Control DNA cleavage experiments using pUC19 supercoiled (SC) DNA and minor groove binder (distamycin) suggest the minor groove binding tendency for the synthesized complexes.

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

“…Cu(II) complexes are preferred candidates for various pharmacostudies due to the presence of its biorelevant ligands which can bind and cleave DNA [17]. The biological behavior of Cu(II) complexes has been subjected to intense investigation for DNA binding and cleavage activities [18] for novel chemotherapeutics and highly sensitive diagnostic agents [19]. Structural features and donor atoms of the complex may influence significant factors such as the lipophilic/hydrophilic nature of the compound, the favoured oxidation state of the copper center, and the observed biological reactivity of the complexes [20].…”