Synthesis, characterization, enzyme inhibition, antioxidant, anticancer and antimicrobial potential of organotin(IV) derivatives of 4-fluorophenoxyacetic acid

Rahim, Shahnaz; Sadiq, Abdul; Javed, Aneela; Noor, Awal; Muhammad, Niaz; Ibrahim, Mohammad; Qayyum, Sadaf; Ayub, Khurshid; Fatima, Nighat; Sarfaraz, Sehrish; Assad, Mohammad; Kubicki, Maciej

doi:10.1016/j.arabjc.2024.105698

Arabian Journal of Chemistry

2024

DOI: 10.1016/j.arabjc.2024.105698

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Synthesis, characterization, enzyme inhibition, antioxidant, anticancer and antimicrobial potential of organotin(IV) derivatives of 4-fluorophenoxyacetic acid

Shahnaz Rahim,

Abdul Sadiq,

Aneela Javed

et al.

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Cited by 4 publications

References 63 publications

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Efficacy of Radical‐Scavenging Activity in Novel Diorganotin(IV) Complexes of Schiff Bases of Salicylaldehyde

Sharma,

Meena

et al. 2024

ChemistrySelect

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Biopotent hybrid diorganotin(IV) complexes, derived from salicylaldehyde Schiff bases having general formula R2SnL, where LH = (OH)C6H4HC: NCR′(R″)CHR‴OH] [where R = Me or Bu], were logically designed, generated, and characterized using spectroscopic techniques, single‐crystal X‐ray investigations, and DFT studies. Different diorganotin(IV) complexes were synthesized because of interaction between diorganotin(IV) dichloride and sodium salts of Schiff bases of salicylaldehyde ligand in anhydrous refluxing THF at 1:1 and 1:2 molar ratio (Product A and B). The chelating property of Schiff bases replaces organo group from diorganotin(IV) dichloride. It creates an O2SnL type of complex when diorganotin(IV) dichloride and ligand interact in 1:2 ratio, which is this study's most fascinating aspect. The characterization of these complexes is aided by physicochemical and spectroscopic investigations, including IR and NMR (1H, 13C, and 119Sn). Single‐crystal X‐ray investigations, mass spectrum studies, and DFT investigations suggest the dimeric structure of these compounds. These diorganotin(IV) complexes have a dimeric structure containing hexacoordinated central tin atom. Two µ2─O atoms bridge the gap between two Sn(IV) atoms in the dimeric dimethyltin(IV) complexes. The DPPH assay results for radical scavenging activity and IC50 values demonstrate the antioxidative potential of diorganotin(IV).

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Efficacy of Radical‐Scavenging Activity in Novel Diorganotin(IV) Complexes of Schiff Bases of Salicylaldehyde

Sharma,

Meena

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

In vitro anticancer, antioxidant, antimicrobial, antileishmanial, enzymes inhibition and in vivo anti-inflammatory activities of organotin(IV) derivatives of 4-bromophenoxyacetic acid

Rahim,

Sadiq,

Javed

et al. 2024

Journal of Molecular Structure

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1,2,3-Triazole functionalized organosilanes as naked eye sensor of Zr (IV) and a potent tyrosinase inhibitor

Singh,

Devi,

Singh

et al. 2024

Journal of Molecular Structure

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Synthesis, characterization, enzyme inhibition, antioxidant, anticancer and antimicrobial potential of organotin(IV) derivatives of 4-fluorophenoxyacetic acid

Cited by 4 publications

References 63 publications

Efficacy of Radical‐Scavenging Activity in Novel Diorganotin(IV) Complexes of Schiff Bases of Salicylaldehyde

Efficacy of Radical‐Scavenging Activity in Novel Diorganotin(IV) Complexes of Schiff Bases of Salicylaldehyde

In vitro anticancer, antioxidant, antimicrobial, antileishmanial, enzymes inhibition and in vivo anti-inflammatory activities of organotin(IV) derivatives of 4-bromophenoxyacetic acid

1,2,3-Triazole functionalized organosilanes as naked eye sensor of Zr (IV) and a potent tyrosinase inhibitor

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