Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid

Petrovic, Dan; Milić, Sandra S. Jovičić; Đukić, Maja B.; Radojević, Ivana D.; Jelić, Ratomir; Jurišević, Milena; Gajovic, Nevena; Arsenijević, Nebojša; Jovanović, Ivan; Marković, Nataša; Stojković, Danijela Lj.; Jevtić, Verica V.

doi:10.1016/j.ica.2021.120601

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…41 Some palladium( ii ) complexes with alkyl esters of ( S , S )-ethylenediamine- N , N ′-di-2-(3-methyl)-butanoic acid show selective and moderate activity. 37 There are studies that indicate a difference in antimicrobial activity between ligands and complexes and it is always higher with palladium( ii ) complexes which is not in agreement with our research. 39,41…”

Section: Resultscontrasting

confidence: 96%

“…41 Some palladium(II) complexes with alkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)-butanoic acid show selective and moderate activity. 37 There are studies that indicate a difference in antimicrobial activity between ligands and complexes and it is always higher with palladium (II) complexes which is not in agreement with our research. 39,41 Like our research some dialkyl esters of ethylenediamine-N, N′-di-S,S-(2,2′-dibenzyl)acetic acid and their platinum(IV) complexes showed different degree of antimicrobial activity in relation to the tested species.…”

Section: Dalton Transactions Papercontrasting

confidence: 96%

“…However, the differences in action are not significant. 37 L4 shows the best effect on Gram-positive bacteria ( Staphylococcus aureus ATCC 25923 and Bacillus subtilis standard and clinical strain). The same ligand also shows good activity on yeasts (62.50–250 μg mL −1 ).…”

Section: Resultsmentioning

confidence: 99%

“…There is a clear difference in the effect of the tested substances on Gram-positive and Gram-negative bacteria. 11,37,38 The influence on G-bacteria was low (Table 4) with exception C2 and L4 (MICs 62.50 μg mL −1 ) on E. coli ATCC 25922. And other studies show that some ligands and palladium complexes show strong antibacterial activity against E. coli.…”

Section: Dalton Transactions Papermentioning

confidence: 99%

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Newly synthesized palladium(ii) complexes with dialkyl esters of (S,S)-propylenediamine-N,N′-di-(2,2′-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding

Ćorović,

Stojković,

Petrović

et al. 2024

Dalton Trans.

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Section: Resultscontrasting

confidence: 96%

Section: Dalton Transactions Papercontrasting

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Dalton Transactions Papermentioning

confidence: 99%

See 2 more Smart Citations

Newly synthesized palladium(ii) complexes with dialkyl esters of (S,S)-propylenediamine-N,N′-di-(2,2′-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding

Ćorović,

Stojković,

Petrović

et al. 2024

Dalton Trans.

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“…In all the cases, absorption intensity increases with an increase in the DNA concentration, i.e., a hyperchromic shift. The hyperchromic change of absorption behavior indicates the groove binding interaction of the complexes with DNA. − It shows a comparable observation of the DNA-complex interaction, as found in the case of the docking experiment, which also suggests minor groove interactions.…”

Section: Resultssupporting

confidence: 57%

Brief Research on the Biophysical Study and Anticancer Behavior of Pt(II) Complexes: Their DNA/BSA Binding, Molecular Docking, and Cytotoxic Property

et al. 2022

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The potent bidentate carrier ligand 2-picolylamine (pic) has been used to synthesize Pt(II) complexes to know their bioactivity and anticancer property as reflected by PASS prediction software. The dichloro Pt(II) complex [Pt(pic)Cl 2 ], Pt-1, and its hydrolyzed diaqua complex [Pt(pic)(OH 2 ) 2 ] 2+ , Pt-2, were synthesized. The thiol-containing Pt(II) complexes [Pt(pic)(Lcys)] + , Pt-3, and [Pt(pic)(L-ac-L-cy)] + , Pt-4, were synthesized from Pt-2, which was obtained from hydrolysis of Pt-1. Their biomolecular interactions with BSA and DNA were executed by spectroscopic methods, and their cytototoxic property was tested by the MTT assay. In vitro biomolecular interactions of Pt(II) complexes with BSA and DNA were investigated by different spectroscopic and viscosity measurement methods for their pharmacokinetic and pharmacodynamic importance. The conformational change of BSA in the presence of a drug candidate was studied by Forster resonance energy transfer calculation and synchronous and three-dimensional fluorescence spectroscopic studies. A theoretical approach on optimization structures, highest occupied molecular orbital−lowest unoccupied molecular orbital energy, global reactivity parameters, time-dependent density functional theory, and molecular docking with BSA and DNA was executed to strengthen and support the experimental observations. In vitro cytotoxic profiles of the complexes like the anticancer activity and their level of reactive oxygen species production were brought under consideration on A549 cancer cells and the normal human embryonic kidney cell line HEK-293. The cytotoxic property was compared with that of the recognized anticancer drug cisplatin.

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Synthesis, characterization, HSA binding, molecular docking, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with propylenediamine derivatives of phenylalanine

Petrovic

Milić

Đukić

et al. 2023

Journal of Inorganic Biochemistry

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Synthesis, characterization, HSA/DNA binding, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with some esters of (S,S)-propylenediamine-N,N'-di-2-(3-methyl)butanoic acid

Cited by 6 publications

References 55 publications

Newly synthesized palladium(ii) complexes with dialkyl esters of (S,S)-propylenediamine-N,N′-di-(2,2′-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding

Newly synthesized palladium(ii) complexes with dialkyl esters of (S,S)-propylenediamine-N,N′-di-(2,2′-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding

Brief Research on the Biophysical Study and Anticancer Behavior of Pt(II) Complexes: Their DNA/BSA Binding, Molecular Docking, and Cytotoxic Property

Synthesis, characterization, HSA binding, molecular docking, cytotoxicity study, and antimicrobial activity of new palladium(II) complexes with propylenediamine derivatives of phenylalanine

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