Synthesis, characterization, in vitro cytotoxicity and antimicrobial investigation and evaluation of physicochemical properties of novel 4-(2-methylacetamide)benzenesulfonamide derivatives

Durgun, Mustafa; Türkmen, Hasan; Zengin, Gülay; Zengin, Hüseyin; Koyunsever, Mehmet; Koyuncu, İsmail

doi:10.1016/j.bioorg.2016.12.007

Cited by 22 publications

(17 citation statements)

References 34 publications

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“…[30][31][32] For NDC-400 th ,anew band associated with phenolic hydroxylg roups appeared at ñ = 3201 cm À1 . [29,34] The chemical linkage between the o-benzenediol-based functional group and NDC is much stronger than that which depends on noncovalent interactions, thus effectively avoiding the detachment of o-benzenediol groups from NDC. [29,34] The chemical linkage between the o-benzenediol-based functional group and NDC is much stronger than that which depends on noncovalent interactions, thus effectively avoiding the detachment of o-benzenediol groups from NDC.…”

Section: Resultsmentioning

confidence: 99%

“…[33] Additionally,t he spectra showed characteristic absorption bands at ñ = 1260 and 1695 cm À1 ,w hich were ascribed predominantly to the amido bonds;t his indicated that ÀCOOH reacted with ÀNHÀ to form amido bonds. [29,34] The chemical linkage between the o-benzenediol-based functional group and NDC is much stronger than that which depends on noncovalent interactions, thus effectively avoiding the detachment of o-benzenediol groups from NDC.…”

Section: Resultsmentioning

confidence: 99%

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o‐Benzenediol‐Functionalized Carbon Nanosheets as Low Self‐Discharge Aqueous Supercapacitors

Xiong

Lee

et al. 2018

ChemSusChem

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Widening the voltage window is often proposed as a way to increase the energy density of aqueous supercapacitors. However, attempting to operate beyond the aqueous supercapacitor stability region can undermine the supercapacitor reliability due to pronounced electrolyte decomposition, which can lead to a significant self-discharge process. To minimize this challenge, charge injection by grafting o-benzenediol onto the carbon electrode is proposed through a simple electrochemical cycling technique. Due to charge injection from o-benzenediol into the carbon electrode, the equilibrium potential of the individual electrode can be reduced. In addition, due to its small molecular size, charge distribution, which is commonly faced by bulk pseudocapacitive materials, is also avoided. The assembled supercapacitor based on the o-benzenediol-grafted carbon demonstrated a maximum energy density of 24 Wh kg and a maximum power density of 69 kW kg , with a retention of 89 % after 10 000 cycles at 10 A g . A low self-discharge of about 4 h was recorded; this could be attributed to the low driving force arising from the lower equilibrium potential. Thus, the proposed technique may provide insight towards the tuning of the equilibrium potential to attain reliable, high-performing supercapacitors with a low self-discharge process.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

o‐Benzenediol‐Functionalized Carbon Nanosheets as Low Self‐Discharge Aqueous Supercapacitors

Xiong

Lee

et al. 2018

ChemSusChem

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“…Cytotoxicity data, where appropriate, were fitted to sigmoidal curves and a four-parameter logistic model was used to calculate the IC 50 values, the concentration of material causing 50% inhibition, compared to the untreated controls. 5-Fluorouracil (5-FU) was also used as a control agent 21 , 22 .…”

Section: Methodsmentioning

confidence: 99%

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides

Çanakçı

Koyuncu

Lolak

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

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In this study, a series of 10 novel copper (II) and silver complexes of 1,3-diaryltriazene-substituted sulfonamides was synthesised. All the synthesised ligands and their metal complexes were assessed for in vitro cytotoxicity against human colorectal adenocarcinoma (DLD-1), cervix carcinoma (HeLa), breast adenocarcinoma (MDA-MB-231), colon adenocarcinoma (HT-29), endometrial adenocarcinoma (ECC-1), prostate cancer (DU-145 and PC-3), normal embryonic kidney (HEK-293), normal prostate epithelium (PNT-1A), and normal retinal pigment epithelium (ARPE-19) cells. Most of the metal complexes from the series showed to be more active against all cancerous cells than the uncomplexed 1,3-diaryltriazene-substituted sulfonamides, and lower cytotoxic effects observed on normal cells. Most of the Cu (II) and Ag (I) metal complexes from the presented series showed high cytotoxic activity against HeLa cells with IC50 values ranging from 2.08 to >300 µM. Specifically, compound L3-Ag showed one of the highest cytotoxicity against all cancer cell lines with IC50 values between 3.30 to 16.18 µM among other tested compounds.

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“…Sulphonamides are a biologically significant group of compounds due to well absorption orally and excrete in urine, thus sulphonamides have less toxicity, increased reactivity and are cost-effective molecules [24][25][26] . Today, sulphonamides are widely used as antimicrobial 27,28 , anti-inflammatory 29,30 , anticancer [31][32][33][34][35][36] and anti-viral agents as well as HIV protease inhibitor 37 , anti-obesity 38 , anti-thyroid 39 , and also act as a potent Carbonic anhydrase hCA inhibitors 40,41 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation, biological evaluation andin silicostudies of sulphonamide Schiff bases

Durgun

Türkeş

Işık

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, 13 C NMR, 1 H NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Their antioxidant activity was determined using different bioanalytical assays such as radical scavenging tests with ABTS þ , and DPPH þ as well as metal-reducing abilities with CUPRAC, and FRAP assays. All compounds showed satisfactory enzyme inhibitory potency in nanomolar concentrations against AChE and CA isoforms with K I values ranging from 10.14 ± 0.03 to 100.58 ± 1.90 nM. Amine group containing derivatives showed high metal reduction activity and about 70% ABTS radical scavenging activity. Due to their antioxidant activity and AChE inhibition, these novel compounds may be considered as leads for investigations in neurodegenerative diseases.

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Synthesis, characterization, in vitro cytotoxicity and antimicrobial investigation and evaluation of physicochemical properties of novel 4-(2-methylacetamide)benzenesulfonamide derivatives

Cited by 22 publications

References 34 publications

o‐Benzenediol‐Functionalized Carbon Nanosheets as Low Self‐Discharge Aqueous Supercapacitors

o‐Benzenediol‐Functionalized Carbon Nanosheets as Low Self‐Discharge Aqueous Supercapacitors

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides

Synthesis, characterisation, biological evaluation andin silicostudies of sulphonamide Schiff bases

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