Synthesis, Characterization, Molecular Docking and in vitro Anticancer Screening of Some Novel Thiophene Derivatives

Abstract

One of the diseases in the 21 st century is still cancer and there is significant research being done all over the world to find a medicine that is more effective and has fewer adverse effects. More than 19 million new cases of cancer have been reported by global statistics and an estimated 10 million people have died from it in 2020. We continue to work on the development of new pharmacological entities because we are motivated in the research area. We have created novel thiophene derivatives and have screened them against the U87-MG cell line to see whether they have any anticancer properties. It was observed that the AP-C12 extract showed the highest inhibition in the U87-MG cell line (EC 50 : 9.1 μM) which was a very good comparison to Temozolomide (EC 50 : 61.2 μM). Similarly, AP-C7 exhibited considerable potency against the U87-MG cell line with EC 50 values of 12.3 μM.

Discovery of Anti‐Breast Cancer Thiophene Sulfonamide Derivatives: Design, Synthesis, Molecular Docking against EGFR, MM‐PBSA, MD Simulations, ADME/Tox, and in vitro Studies

“…Powered K 2 CO 3 (3.0 eq) was added porting wise in to suspension of (7) [37] (1.0 eq) in tetrahydrofuran at room temperature. Sulfonyl chloride (1.2 eq) was added to suspension of (7) & K 2 CO 3 and stirred ambient temperature for 6 hours.…”

“…The promising computational studies encouraged us to synthesize theses thiophene analogues as outline route in Scheme-1. 7 [33][34][35][36][37] was reacted with different substituted sulfonyl chloride to produced compounds APÀ A1 to APÀ A15 (Scheme 1, Table 4).…”

Development of PANI/FeS2/MnO2 Composite Electrode Materials for High‐Performance Supercapacitors

“…The prepared PANI/FeS 2 /MnO 2 composite electrode material coating on the pre-treated nickel foam was used as the working electrode in the three-electrode system and it was used as the positive electrode in the assembled two-electrode device, Ag/AgCl was used as reference electrode, and platinum sheet was used as the counter electrode. [26] The voltage window was 0-0.42 V. The specific capacitance value of the materials can be calculated from the GCD curve by equation (2). [27] C…”

Iron-Catalyzed Oxidative C(sp3)–C(sp3) Radical Coupling Reaction between Thiohydantoins and O-Acetyloximes for the Synthesis of 1,3-Dibenzyl-3,4-dihydropyrrolo[2,3-d]imidazole-2(1H)-thione Derivatives

“…Iron salts are frequently employed as redox catalysts for the formation of C-C and C-X bonds by radical couplings in the syntheses of diverse heterocyclic compounds. [22][23][24][25][26][27][28] Radicals generated from metals energize O-acetyloximes to form bonds with diverse active cycles, giving intermediates that undergo subsequent intramolecular condensation to generate cyclic products. This occurs when the active hydrogen of the thiohydantoin is activated by radical coupling.…”