2018
DOI: 10.22270/jddt.v8i5.1909
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Synthesis, characterization of 2-substituted benzimidazole derivatives and evaluation of antimicrobial activity

Abstract: Benzimidazole has attracted a great deal of importance due to their interesting chemistry and wide utility. Benzimidazole has wide range of uses and applications and is produced in great quantities throughout the world. The current research work was aim to evaluate the in vitro antifungal activity of series of benzimidazole derivatives. A series of benzimidazole derivatives were synthesized by reacting the various amine derivatives of o phenylene diame with carbon disulphide in presence of Potassium hydroxide.… Show more

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Cited by 9 publications
(7 citation statements)
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“…have previously reported the formation of KS 2 CNPh 2 from reaction of Ph 2 NH and CS 2 in the presence of KOH, [32][33][34] but as was the case for NaOH, in our hands this reaction did not work.…”
Section: Paper Dalton Transactionsmentioning
confidence: 49%
See 1 more Smart Citation
“…have previously reported the formation of KS 2 CNPh 2 from reaction of Ph 2 NH and CS 2 in the presence of KOH, [32][33][34] but as was the case for NaOH, in our hands this reaction did not work.…”
Section: Paper Dalton Transactionsmentioning
confidence: 49%
“…While the route for preparation of diaryl DTCs using n BuLi is convenient and high yielding, the use of a pyrophoric base under inert conditions means that it cannot be used in less wellequipped laboratory environments. A number of groups have previously reported the formation of KS 2 CNPh 2 from reaction of Ph 2 NH and CS 2 in the presence of KOH [32][33][34], but as was the…”
Section: Scheme 2 Synthesis Of Lithium Dtc Salts 1a-gmentioning
confidence: 99%
“…The synthesized compounds or derivatives were exposed to antibacterial activity on Bacillus subtilis and Pseudomonas aeruginosa [18]. The standard drug used in this MIC test is ciprofloxacin 2 μg/ml.…”
Section: Antibacterial Activitymentioning
confidence: 99%
“…Numerous properties of benzimidazole substituted derivatives 1-and 1,2-have been described over time. Biological properties of these benzimidazole derivatives include: modulators of cardiovascular activity [11], anticancer potential [4,21], antiparasitic effect [3], antioxidant [20], antibacterial [3,10,17], antifungal activity [1] and antitubercular activities [5]. Benzimidazole derivatives are used successfully in the drug industry.…”
Section: Introductionmentioning
confidence: 99%