Synthesis, characterization of biologically active N, N’ - Bis(4-benzeneazosalicylidene)-o-phenylenediiminatocobalt(ii) complex

Aliyu, HN; Zayyan, RS

doi:10.4314/bajopas.v6i2.27

Cited by 3 publications

(4 citation statements)

References 1 publication

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“…The interaction between Schiff base and metal (II) salt of (manganese, cobalt and nickel) formed complexes with different colours. (Table .1 .1), these temperatures are relatively high indicating the good stability of the complexes due to the formation of large rings, this is closer to the results reported by Aliyu and Zayyan, (2013). The Schiff base and its metal complexes are soluble in some common organic solvents such as Dimethylsulfoxide (DMSO), Dimethylformamide (DMF), methanol, acetone and chloroform, slightly soluble in ethanol and insoluble in water.…”

Section: Discussionsupporting

confidence: 84%

“…The carbonyl group of the aldehyde gives aldimines while that of Ketone gives ketoimines, and these provided binding site for the metal ions through non bonding electrons of the nitrogen. They also have many other hetero-elements like Oxygen and Sulphur which provided binding sites through non bonding electrons (Aliyu and Zayyan, 2013). They are crystalline solids which are feebly basic, but at least some form insoluble salts with strong acids.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and antimicrobial activity of Mn(II), Co(II) and Ni(II) complexes with schiff base derived from 4-chloroaniline and salicylaldehyde

Ibrahim¹,

Yusuf²,

Sambo³

2018

Bayero J. Pure App. Sci.

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Transition Metal Complexes of Mn(II),Co(II) and Ni(II) with Schiff base derived from 4- chloroaniline and Salicylaldehyde were synthesized and characterized by conductivity measurement, magnetic susceptibility, infrared spectra, metal-ligand ratio determination and solubility test. The Schiff base and its metal complexes were tested for antibacterial activity against Staphylococcus aureus and Escherichia coli and fungal activity against Aspergillus flavus and Mucor species. The low molar conductance values range (16-28.1Ohm- cm2 mol-1) indicated that all the complexes are non electrolytes. The magnetic susceptibility revealed that all the complexes are paramagnetic in nature. The metal-ligand ratio was found to be 1:2 in all the complexes. The infrared spectra suggested that the Schiff base behaves as a bidentate ligand. The antimicrobial studies revealed moderate activity against the tested organism when compared with the standards (Ciprofloxacin and Ketoconazole), and this activity increases by increasing concentration. And also the Metal Complexes showed higher activity than free Ligand due to chelation.Keywords: Salicyldehyde, 4-chloroaniline, Mn(II), Co(II), Zn(II) complexes, antimicrobial activity

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial activity of Mn(II), Co(II) and Ni(II) complexes with schiff base derived from 4-chloroaniline and salicylaldehyde

Ibrahim¹,

Yusuf²,

Sambo³

2018

Bayero J. Pure App. Sci.

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“…(Devesh et al, 2014). The nitrogen of the carbonnitrogen double bond is connected to an aryl or alkyl groups but not hydrogen, which provides a binding site for metal ions through its lone pair of electrons (Aliyu and Zayyan, 2013). Schiff base compounds are well employed in coordination chemistry due to their versatility, easy in preparation and ability to form stable complexes (Ignat, 2012).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic determination and in vitro antimicrobial studies of cobalt(ii) and nickel(ii) complexes of a Schiff base derived from 1h-indole-2,3- dione with hydrazinecarbothioamide

Isyaku,

Bello,

Aliyu

et al. 2023

SWJ

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Condensation of H-Indole-2,3-dione with Hydrazinecarbothioamide produced a Schiff base (2Z)-2-(2-Hydroxy-3H-indol-3- ylidinehydrzinE- 1-Carbothioamide. Cobalt(II) and Nickel(II) complexes, were prepared by the interaction of the metal(II) salts with the synthesized Schiff base. The prepared compounds were analysed by magnetic susceptibility, molar conductance, FTIR, AAS, solubility absorbance and empirical formula. The complexes showed moderate values of decomposition temperatures. Infrared spectral data of the Schiff base and the complexes, indicated coordination of the Schiff base to the metal(II) ions via azomethine nitrogen, indole oxygen and thione sulphur. The effective magnetic moment of the complexes suggested an octahedral geometry. The molar conductivities indicated a non- electrolytic nature of these complexes. The results of the absorbance and the empirical formula showed that, the Schiff base is monobasic and tridentate in nature towards the metal ions. Both the ligand and the complexes were screened for antimicrobial activity against Staphylococcus aureus, Salmonella typhimurium, Escherichia coli (bacteria); Aspergillus flavus, Aspergillus fumigatus and Mucor (indicus species) (fungi). Amoxicillin and Ketoconazole were used as positive control for the bacteria and fungi isolates respectively. The results showed that the complexes are more active than the free ligand but less active when compared with the standards.

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“…Hydroxamic acids have attracted an increasing interest during the last few decades due to their wide range of biological activities and low toxicities. These properties have generally been attributed to their ability to chelate metals via the presence of two oxygen atoms [1][2][3] which confer them antibacterial, antifungal, anti-inflammatory, anti-asthmatic, and anticancer activities [4,5] . Several synthetic methods have been reported, with varying degrees of success, for the preparation of hydroxamic acids.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid

Salah

Carraz

Kammoun

2014

JAC

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Naturally occurring hydroxamic acid derivatives are biosynthesized by microorganisms (siderophores) and plants (benzoxazinoids). Recent developments in drug related research have highlighted the promising biological and pharmacological properties that the hydroxamic acid function may offer for the enhancement of therapeutic applications. This study reports on the full synthesis of a new dihydroisoquinoline hydroxamic acid (2-Hydroxy-3,3-dimethyl-7-nitro-3,4dihydroisoquinolin-1(2H)-one). It also describes its cytotoxicity with regard to the human hepatocarcinoma cell line Hep3B.

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Synthesis, characterization of biologically active N, N’ - Bis(4-benzeneazosalicylidene)-o-phenylenediiminatocobalt(ii) complex

Cited by 3 publications

References 1 publication

Synthesis, characterization and antimicrobial activity of Mn(II), Co(II) and Ni(II) complexes with schiff base derived from 4-chloroaniline and salicylaldehyde

Synthesis, characterization and antimicrobial activity of Mn(II), Co(II) and Ni(II) complexes with schiff base derived from 4-chloroaniline and salicylaldehyde

Synthesis, spectroscopic determination and in vitro antimicrobial studies of cobalt(ii) and nickel(ii) complexes of a Schiff base derived from 1h-indole-2,3- dione with hydrazinecarbothioamide

Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid

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