Synthesis, Characterization of C-Zn/Pd-Np as Potential Nanocomposites Against Human Lung Cancer Cells (A549) and Pathogenic Microorganisms

Abstract

PalladiumwrappedZnOnanocomposites synthesis through carrageenan were madeas bimetallic nanocomposites (C-Zn/Pd-Np) and their antibacterial, and anticancer e cacy were assessedunderin vitro condition.Further,they were physico-chemically characterized. The metal complex werecharacterized using a variety of physico-chemical techniques, including scanning electron microscopy (SEM), X-ray diffraction (XRD), and infrared spectroscopy (FT-IR). The bimetallic nanocomposites are more crystalline according to XRD analysis. IR spectra indicate faint multiple bands in the far infrared range because ofmetal-metal interactions and the absence of usual bands of acetate and nitrate groups. P. aeruginosa, S. aureus, B. subtilis andEscherichia coliwere used to test te antibacterial activity of the nanocomposites. The outcomes demonstrated signi cant antibacterial e cacy against all of the investigated pathogens. The antiproliferative effectiveness of the nanocomposites against A549 cancer cell types aresigni cantly enhanced with anincreased concentration.It also resulted in cell cycle arrest, apoptosis, and necrosis found in bimetallic nanocomposites treated cells. In conclusion, (C-Zn/Pd-Np) has notable antibacterial action and is effective against at inhibiting the growth of lung cancer cells. According to this present study, C-Zn/Pd-Np may be useful for the effective clinical management of Human pathogensand lung cancer cells.