Synthesis, Characterization of Ceftibuten-Copper(II) Complex and Prediction of Its Biological Activity

Abstract

Ceftibuten dihydrate, one of the third-generation cephalosporin antibiotic is effectively used in curing several infectious diseases. The complexation of drug with metal may enhance the antibacterial activity. In this work, a new complex of ceftibuten dihydrate with Cu(II) was synthesized, characterized and antibacterial activity is reported. The in vitro test showed that the antibacterial activity of complex of ceftibuten was greatly enhanced against Staphylococcus aureus and Salmonella typhi.

Nickel(II)-Complex of Ceftibuten Dihydrate: Synthesis, Characterization and Thermal Study

“…Analyzing IR data of ceftibuten dihydrate (Figure 3a), it was found that lactam (C=O) and carboxyl (C=O) bands appear at 1770 and 1651 cm -1 , respectively. Like Cu(II)complex 24 of ceftibuten dihydrate, significant changes in the frequency of lactam (C=O) was not observed in Ni(II)-complex of pure drug as well. It means that the carbonyl group of lactam ring was not involved in the formation of coordination complexes of ceftibuten dihydrate.…”

“…29,36 The frequency of 3 o N atom present in β-lactam ring of parent drug is shifted (1361→ 1103 cm -1 ) in the complex, due to involvement of 3 o N atom in chelation. 24,34,35 There was a new peak found at 478 cm -1 in the FT-IR spectrum of the complex [Figure 3(b)] which was due to  (Ni-N). 32 El Tabl et al reported a peak at 480 cm -1 for Ni-N bond in Ni(II)complexes of L-amino acids, used as foliar fertilizers.…”

“…A colored precipitated was obtained after complexation, which was also purified following same procedure as like Cu(II)-complex of ceftibuten dihydrate. 24 The complex was found to be air and moisture stable, dissolved in aqueous medium at 90 o C and organic solvent DMSO, not dissolved in common organic solvents like methanol, ethanol, acetonitrile, acetone and diethyl ether. Yield was obtained as 75% and recorded m.p.…”

“…To verify the synthetic route as reported earlier 24 , the Ni(II)-complex of ceftibuten dihydrate was prepared by maintaining same pH, solvent and temperature of reaction according to scheme-1. The ratio of ligand and metal in the complex formation was maintained at 2:1.…”

“…23 Recently, an article on Cu(II)-complex of ceftibuten dihydrate has been reported from our group. 24 In that work, Cu(II) salt was used as metal source. In current study, Ni(II) complex of ceftibuten dihydrate was synthesized as stated by the methods reported in previous article.…”