Synthesis, characterization of diorganotin(IV) complexes of N‐(2‐hydroxyarylidene)amino‐acetic acid and antitumour screening in vivo in Ehrlich ascites carcinoma cells

Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization, and in vitro cytotoxicity studies

“…On the other hand, the X-ray crystal structure of complex 4 demonstrated a pseudo-trigonal bipyramid geometry around tin atom [58]. The chemical shift data for this complex in CDCl 3 displayed a 119 Sn chemical shift at -340 ppm, which closely matches the shifts reported for diphenyltin(IV) amino acetate [39,41], which has five-coordinate Sn-atoms in solution. This shift testifies that the solid structure of 4, revealed in the crystal structure, is retained in solution.…”

“…In view of the increasing interest in organotin(IV) carboxylates and prompted by their structural diversity [38] and broad therapeutic activity [27], organotin(IV) complexes of Schiff bases derived from amino acids have also been investigated extensively [39][40][41][42][43][44][45][46][47][48][49]. An overview of the coordination behaviour of such Schiff bases towards organotin(IV) is shown in Scheme 1.…”

“…An overview of the coordination behaviour of such Schiff bases towards organotin(IV) is shown in Scheme 1. Some of these organotin(IV) compounds were screened for antitumour activity in vivo in Ehrlich ascites carcinoma cells [41] and cytotoxic activity in vitro against cell lines of human origin [47,49] …”

Synthesis and Characterization of Some Triphenyltin(IV) Complexes from Sterically Crowded [((E)-1-{2-Hydroxy-5-[(E)-2-(aryl)-1-diazenyl]phenyl}methylidene)amino]acetate Ligands and Crystal Structure Analysis of a Tetrameric Triphenyltin(IV) Compound

“…The construction of multidimensional architectures depends on the combination of several factors including the type of organic ligands, tin-R groups, tin coordination geometry preferences and metal-to-ligand molar ratio. The self-assembly of organotin(IV) complexed Schiff bases containing the amino acetate moiety is particularly attractive, since it can be accomplished in one-pot reactions, and the complexes have attracted much interest owing to their novel structural possibilities and therapeutic activity [3][4][5][6][7][8][9][10][11][12][13][14]. Recent reports on the structures of such complexes [3][4][5][6][7][8][9][10][11][12][13][14] show that Schiff base-amino acid systems are …”

Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

“…However, antitumor property of the ligand N-(2-hydroxy acetophenone) glycinate (NHAG) and some of its complexes has been studied [10]. The non-toxic nature, water solubility and strong coordination behavior of NHAG has been under research for some time [11].…”