Synthesis, characterization of new nicotinamide-oxazole analogs, and their antimicrobial activity

Abstract

Identification of a novel antimicrobial molecule is vital to research due to contaminated agro related products and injurious pathogens. Especially candida albicans is most common infective fungi in the present world, that cause hospital-acquired infections. There is a medical and biological need for the discovery of novel antimicrobial drugs with high potent in nature. This effort involved the synthesis of scaffold molecule, in which Vitamin B3 and oxazole plays vital role as pharmacophore moiety, where 2-(Nicotinamido) oxazole-4-Carboxylic acid coupled from pyridine–3-carboxylic acid (Nicotinic acid) and 2-aminooxazole derivative. Then it is characterized by mass spectra, 1H NMR spectroscopy and carried for the growth control ability study against microbial targets such as fungal, and bacterial targets. The Zone of inhibition measured in millimeter for the serially diluted solution of the compound. From the outcomes, the compound (5i) displayed 35mm of inhibition zone area but standard fluconazole showed 29mm for 250 ppm solution. The outcome revealed that the amide bond and oxazole moiety turns as imperative pharmacophore besides showing decent inhibition activities.