Synthesis, Characterization of New Polytriazole Derivatives from Polyacryloyl chloride and Theoretical with Corrosion Inhibitor Study for Stainless steel in acidic medium

Abstract

The purpose of the study is to synthesize and characterize a new polytriazole derivative from polyacryloyl chloried, first reaction of polyacryloyl chloride with hydrazine hydrate in the presence of DMF as a solvent to obtained acid hydrazide (1) than reacted with different amide to give poly 1,2,4-triazole derivatives(1a-1c). Newly synthesized compounds were characterized by spectral methods [13C-NMR, 1H-NMR, and FTIR] and calculated some of its physical properties. Also, we worked theoretical study involving calculated the geometric configurations, total energy, dipole moment etc..,. In addition, the inhibition effect of the synthesized compounds (1a-1c) on corrosion of stainless steel in 1M HCl were studied by method of weight loss. The results of weight loss measurements showed that corrosion inhibition efficiency by increasing the concentration of organic inhibitors for stainless steel in 1M HCl solution at 30oC.

تحوير وتشخيص بعض مشتقات الليفوفلوكساسين الحلقية غير المتجانسة كمثبطات إنزيم Cox-2 وتقييم فاعليتها الحركية الدوائية عن طريق الالتحام الجزيئي ودراسات Adme السويسرية.

“…Physical characteristics, 1 H-NMR, 13 C-NMR, FT-IR spectroscopy, and other methods were used to characterize and identify the produced compounds. The newly created compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) were based in part on the well-known antiinflammatory medication levofloxacin. The Swiss ADME server was used to perform computational techniques, such as ADME studies, in order to forecast the pharmacokinetics of the novel drugs.…”

“…The Swiss ADME server was used to perform computational techniques, such as ADME studies, in order to forecast the pharmacokinetics of the novel drugs. To assess the selectivity of created compounds towards the COX-2 enzyme, the results showed that all compounds met the Lipinski rule of five compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Higher PLP fitness values than the reference compound are predicted by docking studies for ligand interactions with COX-2 protein to bind with amino acids in the active pocket (Levofloxacin ).…”