Synthesis, characterization of undoped and copper-doped hafnium oxide nanoparticles by sol–gel method

Mahendran, N.; Jeyakumar, S. Johnson; Jothibas, M.; Ponnar, M.; Muthuvel, A.

doi:10.1007/s10854-022-08031-0

Cited by 11 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The monoclinic phase NPs resulting from the polymerized precursor method had slightly larger sizes (10−18 nm), and HfCl 4 concentration did not impact crystal structure. Mahendran et al 30 investigated sol−gel derived pristine and copper-doped hafnium oxide NPs. The synthesis mixed HfCl 4 , NaOH, and Cu(NO 3 ) 2 in precursor aqueous solutions.…”

Section: Nanoparticle Synthesismentioning

confidence: 99%

“…Hafnium oxide is also one of the most commonly used antireflection coating materials for optical components due to a high refractive index coupled with a transparent spectral range between infrared and ultraviolet energies coupled and thermal stability . Some hafnium compounds such as hafnium oxide exhibit high chemical inertness and stability with established nanoscale synthesis capacity ,− minimizing toxicity in biological systems and enabling a multitude of medical applications. ,,,− Moreover, an advantageous distribution of mass attenuation coefficient values across the energy spectrum for clinical radiation-based therapy and imaging modalities alongside a well-placed k-edge absorption value lays the groundwork for multifunctional medical applications.…”

Section: Hafniummentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

Skrodzki,

Molinaro,

Brown

et al. 2024

ACS Nano

View full text Add to dashboard Cite

A significant amount of progress in nanotechnology has been made due to the development of engineered nanoparticles. The use of metallic nanoparticles for various biomedical applications has been extensively investigated. Biomedical research is highly focused on them because of their inert nature, nanoscale structure, and similar size to many biological molecules. The intrinsic characteristics of these particles, including electronic, optical, physicochemical, and surface plasmon resonance, that can be altered by altering their size, shape, environment, aspect ratio, ease of synthesis, and functionalization properties, have led to numerous biomedical applications. Targeted drug delivery, sensing, photothermal and photodynamic therapy, and imaging are some of these. The promising clinical results of NBTXR3, a high-Z radiosensitizing nanomaterial derived from hafnium, have demonstrated translational potential of this metal. This radiosensitization approach leverages the dependence of energy attenuation on atomic number to enhance energy−matter interactions conducive to radiation therapy. High-Z nanoparticle localization in tumor issue differentially increases the effect of ionizing radiation on cancer cells versus nearby healthy ones and mitigates adverse effects by reducing the overall radiation burden. This principle enables material multifunctionality as contrast agents in X-ray-based imaging. The physiochemical properties of hafnium (Z = 72) are particularly advantageous for these applications. A well-placed K-edge absorption energy and high mass attenuation coefficient compared to elements in human tissue across clinical energy ranges leads to significant attenuation. Chemical reactivity allows for variety in nanoparticle synthesis, composition, and functionalization. Nanoparticles such as hafnium oxide exhibit excellent biocompatibility due to physiochemical inertness prior to incidence with ionizing radiation. Additionally, the optical and electronic properties are applicable in biosensing, optical component coatings, and semiconductors. The wide interest has prompted extensive research in design and synthesis to facilitate property fine-tuning. This review summarizes synthetic methods for hafnium-based nanomaterials and applications in therapy, imaging, and biosensing with a mechanistic focus. A discussion and future perspective section highlights clinical progress and elaborates on current challenges. By focusing on factors impacting applicational effectiveness and examining limitations this review aims to support researchers and expedite clinical translation of future hafnium-based nanomedicine.

show abstract

Section: Nanoparticle Synthesismentioning

confidence: 99%

Section: Hafniummentioning

confidence: 99%

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

Skrodzki,

Molinaro,

Brown

et al. 2024

ACS Nano

View full text Add to dashboard Cite

show abstract

“…Infrared spectra of the synthesized materials are shown in Figure 7. All three materials have signals at 460 cm −1 , corresponding to metal-oxygen bonds, specifically Si-O and Hf-O bonds [13,23,27]. Inverted peaks at 810 and 1080 cm −1 correspond to symmetrical and asymmetrical molecular vibrations of Si-O-Si bonds [1].…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Catalytic Evaluation of Hafnium Modified SiO2 for the Dehydration of Alcohols

et al. 2023

View full text Add to dashboard Cite

The influence of hafnium metal (Hf) and sulfate ions (SO42−) on the acidic properties of SiO2 mesopores synthesized by a non-hydrothermal method was studied using the following characterization techniques; TG-DTG, XRD, BET, SEM, TEM, EDS, FTIR, n-butylamine titration, FTIR-pyridine, and alcohol dehydration. The incorporation of 3.6% mol of Hf during the silicate synthesis step caused the characteristic structural arrangement of MCM-41 to collapse. However, an increase in the acid strength of the catalyst of up to 315 mV was observed, with Brönsted and Lewis-type acid sites being mostly present therein. Furthermore, the acidity of Hf- and (SO42−) -modified SiO2 in the dehydration of ethanol and methanol was evaluated, resulting in a selectivity towards ethylene and dimethyl ether, respectively. Acid solids have enormous potential to produce important compounds for the chemical industry using alternative routes other than petrochemical processes. They also represent a significant advance for biorefineries.

show abstract