2010
DOI: 10.1016/j.ejmech.2010.08.025
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Synthesis, characterization, oxidative degradation, antibacterial activity and acetylcholinesterase/butyrylcholinesterase inhibitory effects of some new phosphorus(V) hydrazides

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Cited by 31 publications
(22 citation statements)
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“…Gholivand [15] provide interesting studies about new phosphorus(V) hydrazides. Synthesised compounds have not only some antibacterial activity but are able to slow down AChE and BuChE (mainly) activity measured by Ellman's method [16].…”
Section: Introductionmentioning
confidence: 99%
“…Gholivand [15] provide interesting studies about new phosphorus(V) hydrazides. Synthesised compounds have not only some antibacterial activity but are able to slow down AChE and BuChE (mainly) activity measured by Ellman's method [16].…”
Section: Introductionmentioning
confidence: 99%
“…To continue our previous research, and considering the key role of the carbonyl group in the stated configurational change in the phosphorus atom, we chose aliphatic methyl and tert-butyl carbazates with formula NH 2 -NH-CO-OR, R = CH 3 and C(CH 3 ) 3 , respectively, to react with various phosphoryl intermediates, (R 0 ) 2 POCl and R 0 POCl 2 (R 0 = PhO, Ph, PhNH, 4-CH 3 C 6 H 4 O). The 2 J PNH values in the P-NH-N unit are reasonably high [19][20][21][22] and show a strong relationship with the starting phosphoryl reagents. The crystal structure, hydrogen bonding motifs, and intermolecular interactions of compounds 1, 2, and 5 have been further studied.…”
Section: Introductionmentioning
confidence: 87%
“…[12][13][14][15] In addition, phosphorus hydrazides have been considered as biologically relevant materials, when interacting with metallic radioisotopes for potential cancer diagnosis and therapy. 19 Recently, we reported a novel method for the preparation of spiro-bicyclophosphoranes by the reaction of phosphoryl containing reagents with aromatic hydrazides (benzhydrazide and 4-pyridinecarboxylic acid hydrazide), 20 in which the primary phosphorylation is followed by a structural rearrangement to trigonal bipyramidal phosphorus. 19 Recently, we reported a novel method for the preparation of spiro-bicyclophosphoranes by the reaction of phosphoryl containing reagents with aromatic hydrazides (benzhydrazide and 4-pyridinecarboxylic acid hydrazide), 20 in which the primary phosphorylation is followed by a structural rearrangement to trigonal bipyramidal phosphorus.…”
Section: Introductionmentioning
confidence: 99%
“…The first is acetylcholinesterase (AChE, EC.3.1.1.7), which is systematically called acetylcholine acetylhydrolase. The second is butyrylcholinesterase (BChE, EC.3.1.1.8), referred to systemically as acylcholine acylhydrolase (Gholivand et al, 2010). The preferred substrate for AChE enzymes is acetylcholine; BChE enzymes prefer butyrylcholine and/or propionylcholine, depending on the species .…”
Section: A Kinetic Characterization Of Acetylcholinesterase and Butyrmentioning
confidence: 99%