Synthesis, characterization, pH‐sensitive swelling and antimicrobial activities of chitosan–<i>graft</i>‐poly(hydroxyethyl methacrylate) hydrogel composites for biomedical applications

Torğut, Gülben; YAZDIÇ, Ferit Can; Gürler, Nedim

doi:10.1002/pen.26040

Cited by 25 publications

(24 citation statements)

References 41 publications

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“…The antibacterial activities of the films were evaluated according to the Torğut et al, [ 16 ] method. The antibacterial properties of the film samples were fulfilled by the agar well diffusion method.…”

Section: Methodsmentioning

confidence: 99%

“…[11,14] Chitosan is a remarkable polysaccharide in various industries as an edible coating due to its biocompatibility and biodegradability. [5,16] It is used because of its antioxidant, antimicrobial, antifungal, and good coating/film forming properties, acting as a barrier, reducing moisture loss, and improving the respiratory rate of the product. Chitosan also has excellent defense properties against both biotic and abiotic degradation.…”

Section: Introductionmentioning

confidence: 99%

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Development of chitosan/gelatin/starch composite edible films incorporated with pineapple peel extract and aloe vera gel: Mechanical, physical, antibacterial, antioxidant, and sensorial analysis

Gürler

2022

Polymer Engineering & Sci

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In this study, chitosan (C)/gelatin(G)/starch(S) composites incorporated pineapple peel extract (PPE) and aloe vera gel (AVG) were prepared by the casting method as antioxidant agents. Mechanical, water vapor permeability (WVP), moisture content, solubility, opacity, and color properties of the effects of PPE and AVG at different concentrations (0%, 10%, and 30%) were investigated.The prepared films were characterized by Fourier transform infrared spectroscopy in attenuated total reflection (ATR-FTIR), X-ray diffraction (XRD), Thermal gravimetric analysis (TGA), Scanning electron microscope (SEM), mechanical, water barrier, opacity, and color. PPE and AVG extract incorporated edible films improved thermal stability of edible films. Tensile strength decreased with the addition of extracts; the maximum tensile strength was 8.15 MPa for CGS film. The WVP of the films increased with the increasing PPE and AVG concentration. As a biological activity, the films inhibited the growth of gram-positive (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli). With the addition of PPE and AVG to the CGS film, its antioxidant properties were enhanced. In addition, the prepared films were applied for strawberry coating both in the refrigerator and at room temperature. Consequently, these edible-coated films can be used for active food packaging/ coating to extend the shelf life of fruits.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of chitosan/gelatin/starch composite edible films incorporated with pineapple peel extract and aloe vera gel: Mechanical, physical, antibacterial, antioxidant, and sensorial analysis

Gürler

2022

Polymer Engineering & Sci

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“…Hydrogels are three-dimension polymers that can keep a large volume of water that does not dissolve at physiological temperatures and pH but swell in the presence of water. [12,13] Hydrogels in an aqueous environment are often similar to extracellular matrix (ECM). [14,15] They absorb a significant amount of water due to several functional groups such as amino, carboxyl, amide, hydroxyl, and sulfonic, which can be modified and tailored according to their function.…”

Section: Hydrogels With Antibacterial Effectmentioning

confidence: 99%

Antibacterial activity of natural polymer gels and potential applications without synthetic antibiotics

Hamidi

Monajjemzadeh

Siahi‐Shadbad

et al. 2022

Polymer Engineering & Sci

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Antibiotics' use has increased, resulting in disadvantages like patients' drug resistance. Consequently, urgent action is required to develop a new generation of antibacterial agents. Most antibacterial platforms still require a modification with further antibacterial agents (e.g., antibiotics) for adequate antibacterial efficiency. Thus, a nonantibiotic methodology is immediately needed. Furthermore, bactericidal agents used for this purpose are usually based on metal nanoparticles, carbon materials, and polymers. Still, chemicals, antibiotics, and biocides lead to environmental damage. Therefore, the help of biocompatible yet durable materials and polymers is highly appreciated. In addition, if a polymer is not biodegradable, it will remain in the environment for more than one hundred years due to its low degradation rate. Moreover, non‐biodegradable polymers are harmful to in vivo applications. Hence, the use of biodegradable and non‐toxic materials has received many considerations. Over the last few years, the design and synthesis of new polymer gels have gained increasing attention. A polymer gel, also known as a hydrogel, is a three‐dimensional and cross‐linked network filled with water or other liquid solvents. Besides, the hydrogels supercritical drying method results in aerogels, and the freeze‐drying method generates cryogels, where their porous and sponge‐like structures are preserved. Additionally, antibacterial polymer gels are a new generation of polymers considered attractive due to their unique properties. The most recent studies and the latest innovations in polymer gels and hybrid polymers with intrinsic antibacterial properties were discussed in the present review. The reviewed studies from 2015 to April 2022 showed a tremendous revival in research about biopolymer hydrogel, aerogel, and cryogel as antibacterial agents.

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“…The combination of polymers helped to improve material properties (Gürler & Torğut, 2022). Chitosan, a biological polymer of marine origin, was biocompatible, nontoxic biomolecule, and demonstrated the antimicrobial effects against a broad spectrum of bacteria (Yue et al ., 2020; Torğut et al ., 2022). The combination of gelatin with chitosan exhibited improved physical and water stability properties and antimicrobial activity (Matica et al ., 2019).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, and physical properties of chitosan/gelatin composite film incorporated with Caulerpa lentillifera extract for pork preservation

Zhang

Wang

et al. 2023

Int J of Food Sci Tech

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The effects of Caulerpa lentillifera (CL) extract incorporation on antioxidant activity, antibacterial activity, water stability, and physical properties of the chitosan/gelatin (CS/GEL) films were studied. The CL extract containing CS/GEL composite film was prepared by the casting method. The effect of CL content (1%, 3%, 5%) on the antioxidant properties, thermal property, mechanical properties, barrier properties, water stability and water contact angle of CS/GEL films was evaluated. With the increase of CL extract content, bumps and micro-pores appeared on the surface and cross-section of the composite films. The water contact angle, water solubility, and water absorption swelling rate of the composite films were improved with the addition of CL; therefore, the composite films exhibited better water stability. The TS of films were enhanced (from 12.57 to 23.66 MPa). Compared with the normal CS/GEL films, the CS/ GEL-CL films exhibited better antioxidant with DPPH scavenging capacity values of 72.6% and could effectively slow down the lipid oxidation of refrigerated pork samples during storage, such as lower accumulation of free fatty acid content and fluorescence compound formation. This suggested that CS/GEL-CL film might be suitable as active films for food packaging.

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Synthesis, characterization, pH‐sensitive swelling and antimicrobial activities of chitosan–graft‐poly(hydroxyethyl methacrylate) hydrogel composites for biomedical applications

Cited by 25 publications

References 41 publications

Development of chitosan/gelatin/starch composite edible films incorporated with pineapple peel extract and aloe vera gel: Mechanical, physical, antibacterial, antioxidant, and sensorial analysis

Development of chitosan/gelatin/starch composite edible films incorporated with pineapple peel extract and aloe vera gel: Mechanical, physical, antibacterial, antioxidant, and sensorial analysis

Antibacterial activity of natural polymer gels and potential applications without synthetic antibiotics

Antioxidant, and physical properties of chitosan/gelatin composite film incorporated with Caulerpa lentillifera extract for pork preservation

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