Synthesis, characterization, theoretical, anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA gyrase inhibitor

Chalcones and their therapeutic targets for the management of diabetes: Structural and pharmacological perspectives

“…The privileged scaffold chalcone remained a fascination among researchers in the 21st Century due to its simple chemistry, ease of synthesis, diversity of substituents, wide range of biological activities such as anti-diabetic [16], anti-neoplastic [17], antihypertensive [18], anti-retroviral [19], anti-inflammatory [20], anti-parasital [21], anti-histaminic [22], anti-malarial [23], antioxidant [24], anti-fungal [25], anti-obesity [26], anti-platelet [27], anti-tubercular [28], immunosuppressant [29], anti-arrhythmic [30], hypnotic [31], anti-gout [32], anxiolytic [33], anti-spasmodic [34], anti-nociceptive [35], hypolipidemic [36], anti-filarial [37], anti-angiogenic [38], anti-protozoal [39], anti-bacterial [40], antisteroidal [41], etc. The term "chalcone" was coined by Kostanecki, who synthesized a series of natural chromophoric products for the first time.…”

Single X-ray crystal and spectroscopic investigation of novel biologically active donor–acceptor chalcones as specific application for opto-electronics and photonics

“…The effective number of electrons transition from the ground to excited state is usually described by the oscillator strength, which provides the absorption area in the electronic spectrum. The oscillator strength, f, can be calculated using the following equation [27]: f = 4.32 × 10 −9 ε (ν) dν (4) where ε is the extinction coefficient (l mol −1 cm −1 ), andν represents the numerical value of wavenumber (cm −1 ). Oscillator strength values of compound (1 & 2) in different solvents are reported in Tables 6 and 7.…”

“…Chalcones are the condensation product of acetophenone with aromatic aldehydes in the presence of strong base [2]. They exhibit a wide range spectrum of biological activities such as anti-bacterial [3], anti-oxidant [4], anti-inflammatory [5], anti-cancer [6] and antiviral [7]. Cyclization of chalcones gives the various heterocyclic compounds such as pyrazole, pyrimidine and pyridine by a nucleophilic addition reaction which enhanced the biological activities [8][9][10][11].…”

Investigation of 2-hydroxy-4-methoxy-2′,3′-benzochalcone binding to tubulin by using NMR and in silico docking

“…Owing to their diverse biological activities including DNA gyrase inhibition, anti-tumorigenesis, P-glycoprotein inhibition, and cell growth inhibitory effects on the cisplatin-resistant ovarian cancer cells, their derivatization has been researched widely (Abdullah et al, 2014;Parveen et al, 2014;Shin et al, 2014;Zhou et al, 2014). Hydroxychalcones act as autophagy inducers and methoxychalcones induce apoptosis (Sun et al, 2010;Wang et al, 2014).…”