Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes

Agarwal, Shilpa; Baroliya, Prabhat Kumar; Bhargava, Amit; Tripathi, I. P.; Goswami, A. K.

doi:10.1016/j.bmcl.2016.04.051

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…Hydroxytriazene is a bidentate ligand which has alpha hydroxyl group relative to azo group and diazo group. This class of compounds have analytical applications as they from chelate complex with most of transition metals ( Naulakha et al., 2009 ; Panwar et al., 2014 ; Singh et al., 2008 ) and they also have broad spectrum of biological activities such as lipid lowering, antioxidant, antidiabetic, anti-inflammatory, antifungal, antibacterial, insecticidal and analgesic agents ( Sharma et al., 2020 ; Regar et al., 2016 ; Agarwal et al., 2016 ; Baroliya et al., 2014 ; Jain et al., 2020 ; Hura et al., 2003 ; Chauhan et al., 2007 , 2010 ; Khanam et al., 2014 ; Goswami et al., 2012 ; Rezaie et al., 1997 ; Goswami, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs

Dayma

Chopra

Sharma

et al. 2020

Heliyon

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The present study is aimed to investigate the anti-inflammatory, antioxidant and antidiabetic activities of three series of hydroxytriazenes based on sulfa drugs viz; Sulphathiazole (ST), Sulfisoxazole (SF) and Sulphamethoxazole (SM). Antidiabetic activities of the synthesized hydroxytriazenes were investigated by α-glucosidase and α-amylase inhibition method and IC 50 values were recorded. The compounds presented significant α-glucosidase and α-amylase inhibition effect with IC 50 values ranging from 122 to 341 μg/mL. Anti-inflammatory activity was also investigated by carrageenan-induced paw edema (CPE) method, where % inhibition was up to 89% after 4 h of treatment and antioxidant properties of the similar compounds were assessed by DPPH and ABTS radical scavenging assays. Antioxidant capacity of all the hydroxytriazenes detected by ABTS assay, was significantly higher as compared to DPPH assay. The hydroxytriazenes having highest antioxidant capacity presented IC 50 values for compound ST-1 and ST-6 are 488 μg/mL for DPPH, 54.12 μg/mL for ABTS and 858.5 μg/mL for DPPH, 48.0 μg/mL for ABTS, respectively. These results suggested that ABTS assay may be more useful than DPPH assay for synthetic antioxidants. The findings from the molecular docking experiments may also expand the formation of new potent sulpha drugs based hydroxytriazenes targeting towards the subunit of C-terminal of human maltaseglucoamylase for the treatment of diabetes metabolic disorder. Overall, highlight the multifunctional role of hydroxytriazenes as antidiabetic, antioxidant and anti-inflammatory agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs

Dayma

Chopra

Sharma

et al. 2020

Heliyon

Self Cite

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A Versatile Pre and Post Ugi Modification for the Synthesis of Natural Product Inspired Fused Peptide‐Carboline Scaffolds as Potential Anti‐Leishmanial Agents

et al. 2019

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A series of novel β‐carboline‐peptide (5 a‐5 f)/ tetrahydro‐β‐carbolines‐peptide (10 a‐10 f) has been synthesized via natural product inspired molecular hybridization approach. All the hybrids were examined for their anti‐leishmanial potential. Most of the screened derivatives exhibited significant in vitro anti‐leishmanial activity against promastigote and intracellular amastigotes (IC50 ranging from 2.43 to 7.61 μM) than the control, miltefosine (IC50 = 8.2 μM), with less cytotoxicity in comparison to the standard drugs (sodium stibogluconate, and miltefosine). Compound 5 a was also able to inhibit Leishmania donovani TR (LdTR). A molecular modeling study based on docking and subsequent binding free energy evaluation was carry out in the active site of LdTR to understand their possible binding site. Our results show that prototype 1(5 a‐5 f) & 2 (10 a‐10 f) represent a new structural lead for anti‐leishmanial Chemotherapy.

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Hydroxytriazenes incorporating sulphonamide derivatives: evaluation of antidiabetic, antioxidant, anti-inflammatory activities, and computational study

et al. 2022

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Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes

Cited by 6 publications

References 14 publications

Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs

Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs

A Versatile Pre and Post Ugi Modification for the Synthesis of Natural Product Inspired Fused Peptide‐Carboline Scaffolds as Potential Anti‐Leishmanial Agents

Hydroxytriazenes incorporating sulphonamide derivatives: evaluation of antidiabetic, antioxidant, anti-inflammatory activities, and computational study

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