Chalcogenides are basically one chalcogen anion with a more electropositive cation. Selenium, Tellurium and Sulfur based chalcogenides are used widely with a variety of applications. Chalcogenides are known as an IR transmission and high reflective index, with a wide range of applications in catalyst technologies and sensing devices. It is possible to make chalcogenides in various forms like nanocrystals, thin films and bulk crystals based on the requirement. Chalcogenides are categorized as binary (2°), ternary (3°), quaternary (4°), and penternary (5°) based on their structural differences. These compounds have a high degree of versatility for modifying the bandgap without the use of hazardous components. The structural and chemical property analysis will help us to tailor the chalcogenides-based material for the suitable application and reveal the science behind this important class of materials. The diverse size synthesis of chalcogenides, encompassing nano, micro, and macro scales, is crucial for tailoring their properties to meet specific applications, ranging from nanoscale innovations in quantum dots for advanced electronics to microscale developments in thin-film solar cells for efficient photovoltaics, and macroscale applications in solid-state memory devices and radiation detectors, showcasing the versatile impact of size-tailored chalcogenides across a spectrum of technologies.