Synthesis, chemical and biological investigations of new Ru(III) and Se(IV) complexes containing 1,3,5-triazine chelating derivatives

Al-Khodir, F. A. I.; Al‐Warhi, Tarfah; Abumelha, Hana M.; Alissa, Siham A.

doi:10.1016/j.molstruc.2018.11.082

Cited by 15 publications

(12 citation statements)

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“…Synthesis of N 2 ,N 4 ,N 6 -triaryl-1,3,5-triazine-2,4,6-triamine primary nucleus (Figure 2) was carried out as described in literature [30, 31]. The synthesis of L 1 , L 2 , L 3 , and L 4 triazine ligands was carried out according to our previously work [29], L 1 prepared by stirring the mixtures of 2-aminopyrimidine with 6-chloro-N 2 -(4-chlorophenyl)-N 4 -di(pyrimidin-2-yl)-1,3,5-triazine-2,4-diamine in dioxane at refluxed temperature; L 2 prepared by stirring the mixtures of 2-aminothiazole with 6-chloro-N 2 -(4-chlorophenyl)-N 4 -(pyrimidin-2-yl)-1,3,5-triazine-2,4-diamine in dioxane at refluxed temperature; L 3 prepared by stirring the mixtures of 2-aminopyrimidine with 4,6-dichloro-N 2 -(1H-1,2,4-triazol-3-yl)-1,3,5-triazin-2-amine in dioxane 50°C; L 4 prepared by stirring the mixtures of 2-aminopyrimidine with 4,6-dichloro-N-( 4-chlorophenyl)-1,3,5-triazin-2-amine in dioxane 50°C.…”

Section: Methodsmentioning

confidence: 99%

“…Structures of prepared triazine ligands [29]. L 1 = N 2 -(4-chlorophenyl)-N 4 ,N 6 -di(pyrimidin-2-yl)-1,3,5-triazine-2,4,6-triamine .…”

Section: Figurementioning

confidence: 99%

“…In connection of our previously work [29], this article aimed to synthesized new platinum(IV) and palladium(II) complexes with four triazine ligands (Figure 1) and checked the biological property and anticancer significance.…”

Section: Introductionmentioning

confidence: 99%

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New Platinum(IV) and Palladium(II) Transition Metal Complexes of s-Triazine Derivative: Synthesis, Spectral, and Anticancer Agents Studies

Al-Khodir

Abumelha

Al‐Warhi

et al. 2019

BioMed Research International

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New Pd(II) and Pt(IV) triazine complexes [Pt3(L1)2(Cl)9(H2O)3].3Cl.3H2O (1), [Pt3(L2)2(Cl)9(H2O)3].3Cl (2), [Pt3(L3)2(Cl)9(H2O)3].3Cl (3), [Pt2(L4)2(Cl)6(H2O)2] .2Cl.4H2O (4), [Pd3(L1)2(H2O)6] .3Cl2 (5), [Pd3(L2)2(H2O)6].3Cl2 (6), [Pd3(L3)2(H2O)6].3Cl2 (7), and [Pd2(L4)2(H2O)4].2Cl2 (8) were synthesized and well characterized using elemental analyses, molar conductance, IR, UV-Vis, magnetic susceptibility, 1H, 13C-NMR spectra, and thermal analyses. These analyses deduced that the L1, L2, and L3 ligands act as tridentate forming octahedral geometry with Pt(IV) metal ions and square planar geometry in case of Pd(II) complexes but the L4 ligand acts as bidentate chelate. The molar conductance values refer to the fact that all the prepared s-triazine complexes have electrolyte properties which are investigated in DMSO solvent. Surface morphology behaviors of prepared complexes have been scanned using TEM. The crystalline behavior of triazine complexes has been checked based on X-ray powder diffraction patterns. The antimicrobial activity of the free ligands and their platinum(IV) and palladium(II) complexes against the species Staphylococcus aureus (G+), Escherichia coli (G−), Aspergillus flavus, and Candida albicans has been carried out and compared with the standard one. The coordination of ligands towards metal ions makes them stronger bacteriostatic agents, thus inhibiting the growth of bacteria and fungi more than the free ligands. The cytotoxic assessment IC50 of the free ligands and its platinum(IV) complexes in vitro against human colon and lung cancer cell lines introduced a promising efficiency.

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Section: Methodsmentioning

confidence: 99%

“…Structures of prepared triazine ligands [29]. L 1 = N 2 -(4-chlorophenyl)-N 4 ,N 6 -di(pyrimidin-2-yl)-1,3,5-triazine-2,4,6-triamine .…”

Section: Figurementioning

confidence: 99%

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New Platinum(IV) and Palladium(II) Transition Metal Complexes of s-Triazine Derivative: Synthesis, Spectral, and Anticancer Agents Studies

Al-Khodir

Abumelha

Al‐Warhi

et al. 2019

BioMed Research International

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“…Among the synthesized metal complexes, the [Ru(Ln) (Cl) x (H 2 O) y ] z Cl], 344-347 (Scheme 117) showed promising antimicrobial and anticancer activities. [200] For applications of nanoparticles in heterogeneous catalysis, Niembro et al in 2008 reported a new palladium based s-triazine nanoparticles 351 embedded in fluorous organic-inorganic hybrid material (Scheme 118). The palladium nanoparticles employed as a heterogeneous catalyst for the Heck coupling reaction under microwave irradiation.…”

Section: S C H E M E 8 1 Synthesis Of Ag(i)-complexes 208 and 209 With Bis-pyrazolo-s-triazine Ligandmentioning

confidence: 99%

“…Fuel cells Kamiya et al [98] [Pt 3 IV (TPTZ)Cl 8 ]Cl 4 Tumor treatment Al-Assy et al [100] Antimicrobial activity Al-Khodir et al [199] [Ru(Ln)(Cl) x (H 2 O) y ] z Cl] Antimicrobial and anticancer activities Al-Khodir et al [200] Palladium nanoparticles Heterogeneous catalyst for the Heck coupling reaction under microwave irradiation Niembro et al [201] Tetranuclear dysprosium complexes Magnetism Lu et al [203] (Continued)…”

Section: Complex Applicationmentioning

confidence: 99%

s‐Triazine pincer ligands: Synthesis of their metal complexes, coordination behavior, and applications

Barakat

El‐Faham

Haukka

et al. 2021

Applied Organom Chemis

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Pincer ligands are interesting chelating agents due to their high ability to motivate the metal ion characteristics leading to diverse types of applications. These ligands and their metal complexes are smart materials which have a great impact in the development of diverse applications helped alot in the advancement of the field of coordination chemistry. In homogenous catalytic transformations, pincer ligands improved the chemical and thermal stability that serve to minimize the leaching of the metal during the catalytic cycle. Also, they offered the ability to fine‐tune the electronic properties for the metal center, thereby increasing the scope of their coordination chemistry and applications especially the pincer ligands comprising s‐triazine core. This review discusses some of the general synthetic protocols of these s‐triazine pincer ligands and their metal complexes with various applications in different fields. In addition, their structural diversity and the ligand coordination behaviors with different metal ions were also explored.

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Potential of triazines in Alzheimer's disease: A versatile privileged scaffold

Gharat

Prabhu

Khambete

2022

Archiv der Pharmazie

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Triazines are six-membered privileged scaffolds that have been explored in drug discovery programs owing to their stability in biological media and robust reactivity.Their unique chemical properties have led to the exploration of the triazinecontaining molecules for multifaceted disorders like Alzheimer's disease (AD). The pathology of AD involves the interplay of multiple biochemical events such as amyloid beta-aggregation, formation of reactive oxygen species, cholinergic degradation, and metal ion dysregulation. The growing incidence of AD, coupled with the limited availability of efficacious medicines, necessitates the identification of newer therapeutic approaches. Privileged scaffolds like triazines with the potential for multiple biological effects offer excellent alternatives to the treatment of multifactorial AD. The present review describes numerous triazine-containing molecules capable of modulating single as well as multiple pathological factors involved in AD.The analysis of structural features of these molecules can provide useful insights for developing newer therapies.

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Synthesis, chemical and biological investigations of new Ru(III) and Se(IV) complexes containing 1,3,5-triazine chelating derivatives

Cited by 15 publications

References 50 publications

New Platinum(IV) and Palladium(II) Transition Metal Complexes of s-Triazine Derivative: Synthesis, Spectral, and Anticancer Agents Studies

New Platinum(IV) and Palladium(II) Transition Metal Complexes of s-Triazine Derivative: Synthesis, Spectral, and Anticancer Agents Studies

s‐Triazine pincer ligands: Synthesis of their metal complexes, coordination behavior, and applications

Potential of triazines in Alzheimer's disease: A versatile privileged scaffold

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