Synthesis, comparative theoretical and experimental characterization of some new 1,3,5 triazine based heterocyclic compounds and in vitro evaluation as promising biologically active agents

Synthesis, combined theoretical and spectral characterization of some new 1,3,5 triazine compounds, and their in vitro biological analysis

“…The pH was maintained at 5–6 by using dilute HCl. 11,24 The completion of reaction was confirmed by the above mentioned procedure. The product was neutralized, filtered, dried and purified (Scheme 1).…”

“…The product was neutralized once the reaction was completed. 11,24 After completion of the reaction, the solution was brought to room temperature, and the precipitate was filtered and washed with diethyl ether. Further purification was carried out with n-hexane : ethyl acetate (7.5 : 2.5 V/V) by column chromatography to obtain mono-and di-substituted 1,3,5-triazine derivatives in solid form in a very good yield and purity.…”

“…23 Noureen et al reported di-substituted s-triazine compounds as promising biologically active compounds with excellent antibacterial and antifungal potential. 24 Encouraged by the above-mentioned importance of 1,3,5 triazine in designing and synthesizing new inexpensive, commercially viable, stable, and pharmaceutically potent compounds, we focused on the exploration of triazine derivatives for their broad biological applications. The hybrid molecule may be designed by combining different pharmacophores in one structure with increased biological potential.…”

“…23 Noureen et al reported di-substituted s -triazine compounds as promising biologically active compounds with excellent antibacterial and antifungal potential. 24…”

Recent biological applications of heterocyclic hybrids containings-triazine scaffold

“…Being a versatile scaffold, s -triazine is found to be a very potent antibacterial agent. To evaluate this antibacterial activity, molecular hybrids [( 60a ) and ( 60b )] of s -triazine and pyrimidine with additional sulfonamide moiety 69 were synthesized in good yield and characterized theoretically and experimentally. Through SAR analysis, it was observed that when s -triazine is tethered to the pyrimidine ring its activities are enhanced meanwhile, when the sulfonamide group is attached activity is also increased since it has a synergic effect on the s -triazine ring.…”