Synthesis, complex stability and small animal PET imaging of a novel ⁶⁴Cu-labelled cryptand molecule

Abstract

The radiosynthesis and radiopharmacological evaluation including small animal PET imaging of a novel 64Cu-labelled cryptand molecule ([64Cu]CryptTM) possessing a tris-pyridyl/tris-amido set of donor atoms is described.

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

“…Any loss of copper will lead to the biodistribution being dominated by biological copper metabolic pathways. 3,4 Ligands such as cross-bridged cyclams 5 and cryptands 6 are, to date, the most promising. Here, we report the potential of modified single-walled nanotubes (SWNTs) to both contain and deliver radiocopper in an aqueous environment as a superior alternative to chelators.…”

Interaction studies of lead(II) ion with cyclic β‐(1→3),(1→6) glucans extracted from Bradyrhizobium japonicum based on ‘chelation enhanced fluorescence’ (CHEF) effect

“…A plethora of methods has been reported for remediation of lead contaminated soils for example, the in situ stabilization of lead in soil using phosphorous compounds . Macrocyclic compounds such as cryptands, crown ethers, calixarenes, etc., have been used as complexing agents and are of great interest because of their promising applications as supramolecular scaffolds in host–guest complex chemistry.…”