Synthesis, Crysta Structure, and Some Propertie of 4-Hydroxymethylpyridinium Hexafluorosilicate

Bis(2‐, 3‐, 4‐carboxyethylpyridinium) hexafluorosilicates as potential caries prophylactic agents

“…In turn, the observed general tendency towards a significant decrease in solubility of ionic complexes I-III upon going from solutions in highly polar water and DMSO solvents to less polar alcoholic media is generally quite expected, and the decrease in solubility of these salts in ethanol compared to methanol may reflect the relative "lipophilization" of the medium. Note that a qualitatively similar trend in the change of solubility in the above-mentioned media was found for 2-, 3-, 4carboxymethylpyridinium [21] and 3-, 4-hydroxymethylpyridinium [22,23] hexafluorosilicates.…”

“…[ 42,43 ] The only known exception is 2‐amino‐4,6‐dihydroxypyrimidinium hexafluorosilicate, the use of which, in contrast to the action of NaF and (NH 4 ) 2 [SiF 6 ], has led to a significant increase in ALT activity (by 39%). [ 44 ]…”

“…[ 19,20 ] In turn, AHFSs, whose cations exhibit antibacterial, anti‐inflammatory, and other types of biological activity, demonstrate in experiments an increase in anticaries effect in comparison with the reference drugs, such as NaF, and even (NH 4 ) 2 [SiF 6 ]. [ 13,18 ] Our recent findings [ 21 ] show that of considerable interest are the AHFSs with substituted pyridinium cations [ 22,23 ] since these compounds reveal high WS, acceptable toxicological characteristics, and a wide spectrum of biological activity typical for pyridine ligands. [ 24‐26 ] In particular, hitherto unknown 2‐, 3‐, 4‐carboxyethylpyridinium hexafluorosilicates, whose cations contain a –CH 2 CH 2 COOH moiety, as a fragment of a well‐known pharmacophore, propionic acid possessing an anti‐inflammatory activity, are among the promising anticaries agents.…”

Identification of Ammonium Hexafluorosilicates Using Chemical Methods of Analysis

“…Ідентифікацію гексафторосилікатного аніону у складі солей I-IV здійснювали за реакціями білого помутніння за рахунок утворення кальцію фториду (9) та плюмбуму (II) фториду (10) при взаємодії водних розчинів I-IV з розчинами кальцію хлориду та плюмбуму (II) ацетату [13]. Поряд із фторидами кальцію та плюмбуму є ймовірність утворення гексафторосилікату кальцію за рахунок часткового гідролізу досліджуваних солей:…”