Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol

Hydrogen bonding in 2,6-bis(4-fluorophenyl)-3,5-dimethylpiperidin-4-one methanol solvate

“…In the 13 C NMR spectrum, the extreme downfield signal at δ 186.48 ppm is readily assigned to the carbonyl carbon. Due to the presence of fluoride in the aryl ring, all the aryl carbons appeared as doublets.…”

“…Piperidin-4-one molecules are well known for their therapeutic applications and therefore great effort is directed toward the synthesis and characterisation of new derivatives. Specifically, piperidine derivatives are reported to exhibit anti-bacterial [12,13] anti-fungal, central nervous system (CNS) stimulating, depressant and analgesic [14,15], antitubercular [16], anti-cancer [17,18] anti-oxidant and anticonvulsant [19] activities. The significant biological activities of piperidin-4-one derivatives are often associated with the aryl substituents at the positions on either side of the amine group [18,20].…”

Facile sulfur‐assisted carbonylation of diaminoresorcinol with carbon monoxide

“…Furthermore, 2-mercaptobenzoxazole synthesis from 2-aminophenol is well known using carbon disulfide [9][10][11][12][13][14] or potassium O-ethyl dithiocarbonate [15][16][17]. Then, we also performed research to find another equivalent of 4,6-diamino-resorcinol by the thiocarbonylation of 2a with carbon disulfide.…”

Synthesis, spectral characterization and DFT analysis for the validation of 2, 6 diaryl -piperidin-4-ones as potential sunscreens and UV filters

“…In particular, they were known for their antibacterial [1,2], antifungal [3,4], antituberculosis [5], anticancer [6,7], antioxidant, anti inflammatory [8], CNS stimulant and depressant and analgesic [3] activities. The significant biological activities of piperidin-4-one derivatives are often associated with aromatic substituents at the 2 nd and 6 th positions [9,10].…”