Synthesis, crystal structure analysis, biological activity and molecular docking studies of (E)-4-amino-N'-(1-phenylethylidene)benzohydrazide

Senthilkumar, S.; Seralathan, J.; Muthukumaran, G.

doi:10.1016/j.cdc.2020.100514

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…Among all molecules, docking of GlcNÀ 6-P synthase with 4 a,4 f and 4 g revealed that their binding energy were À 6.27, À 6.31 and À 6.43 kJ/mol, respectively which was comparable to the binding energy of the standard ciprofloxacin (À 6.11 kJ/mol) used, which can be predicted as a good inhibitor of GlcNÀ 6-P synthase.These results correlate well with the in vitro antimicrobial activity, whereas in 4 a,4 f and 4 g showed more potent antibacterial activity than the literature report on urea derivatives. [42,45,46]…”

Section: Chemistryselectmentioning

confidence: 99%

8‐Nitronaphthofuran Fused Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Characterization and Pharmacological Studies

Shruthi

Yallappa²,

Mallikarjuna

et al. 2023

ChemistrySelect

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Urea and its derivatives are an important class of compounds with diverse chemical and biological properties that are widely used in the chemical, pharmaceutical, and agrochemical industries. The present work focuses on the synthesis of 8nitronaphthofuran fused urea-derivatives (4 a-j) and exploring their potent antimicrobial and antioxidant activities. The chemical structures of the synthesized compounds were determined by different physicochemical techniques. The antimicrobial and antioxidant activities are carried out and tested compounds showed considerable activity compared to the standard drugs. To justify the bio-efficacy of the newly synthesized compounds; the bio-activity results are compared with the in silico molecular docking study against the target enzyme glucosamine-fructose-6-phosphate aminotransferase and demonstrated effective hydrogen bonding affinity.

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Section: Chemistryselectmentioning

confidence: 99%