Synthesis, crystal structure and antibacterial activity of a novel phenolato- and peroxo-bridged dinuclear cerium(IV) complex with tripodal Schiff bases

Sang, Ya-Li; Lin, Xue-Song; Li, Xiaochun; Liu, Yanhua; Zhang, Xinhao

doi:10.1016/j.inoche.2015.11.003

Cited by 18 publications

(9 citation statements)

References 31 publications

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“…Complexes [ 2 ] + and 3 adopt a typical three-leg piano-stool geometry, and the bonding parameters around the Ru(II) center are similar to those previously reported for [(η 6 - p -cymene)RuCl 2 (κ P -PR 3 )] and related compounds. ,− , The structure of the neutral complex 3 , as found in both 3 ·CH 3 COCH 3 and 3 ·[ 2 ]Cl, is closely related to those of the already reported [(η 6 - p -cymene)RuCl 2 {κ P -PPh 3 }] and [(η 6 - p -cymene)RuCl 2 {κ P -PPh 2 (4-C 6 H 4 CO 2 H)}] . Cation [ 2 ] + within 3 ·[ 2 ]Cl represents a rare example of (η 6 -arene)Ru complex with a κ 2 P , O -coordinated phosphino-alcohol; , by a different point of view, the chelating κ 2 P , O coordination exhibited here by (2-diphenylphosphino)phenol is rather uncommon (see the Introduction).…”

Section: Resultssupporting

confidence: 81%

“…Hemilabile ligands play a prominent role in coordination chemistry, since their reversible binding to one metal site is crucial to the effectiveness of many metal mediated processes . In this regard, a number of heteroditopic P , O -donors have been reported to behave as hemilabile ligands, most of the examples being referred to phosphines containing an additional ether, carbonyl, − , or phosphine-oxide functionality. , However, the hemilability properties of phosphino-alcohols have been much less developed, as a consequence of the increased acidity of the OH unit when approaching the metal center, thus facilitating the formation of stable metal-alkoxide derivatives via deprotonation . This process is even more favorable when dealing with phosphino-phenols, due to the superior acidity of the phenolic group .…”

Section: Introductionmentioning

confidence: 99%

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Solvent-Dependent Hemilability of (2-Diphenylphosphino)Phenol in a Ru(II) para-Cymene System

et al. 2018

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The addition of Ph2P(2-C6H4OH) to [(η6-p-cymene)RuCl(μ-Cl)]2 led to the formation of three distinct products, depending on the experimental conditions. The previously reported [(η6-p-cymene)RuCl{κ2 P,O-PPh2(2-C6H4O)}], 1, was obtained in 90% yield using MeOH as the solvent, in the presence of a base (Et3N). Conversely, [(η6-p-cymene)RuCl{κ2 P,O-PPh2(2-C6H4OH)}]Cl, [2]Cl, was afforded (88% yield) in MeOH without using the base. However, [(η6-p-cymene)RuCl2{κP-PPh2(2-C6H4OH)}], 3, was the major species in chlorinated solvents. Compounds 1, [2]Cl, and 3 were characterized by analytical and spectroscopic (IR, NMR) methods. The X-ray structures of [2]+ and 3 were determined, with the latter forming hydrogen bond dimeric units in the solid state. The dissolution of [2]Cl into a series of deuterated solvents, except methanol, led to rapid equilibration between [2]Cl and 3, revealing the hemilabile behavior of the phosphino-phenol ligand. According to Pulsed-Field Gradient Spin Echo (PGSE)-NMR and DFT studies, the dimeric nature of 3 persists in solution; thus, the hydrogen-bonding properties of MeOH are crucial to stabilize [2]Cl with respect to 3, with the latter being 3.4 kcal mol–1 more stable than the former in the gas phase. Compound 1 underwent electrophilic additions by HCl, HBF4, and MeCOCl to give, respectively, [2]Cl (the reverse process being viable with Et3N), [2]BF4, and the ester [(η6-p-cymene)RuCl2{κP-PPh2(2-C6H4OCOMe)}], 5. The reaction of 1 with AgNO3 afforded the nitrate complex [(η6-p-cymene)Ru(NO3){κ2 P,O-PPh2(2-C6H4O)}], 4. Compounds [2]BF4, 4, and 5 were isolated in the solid state in good to high yields and characterized by elemental analysis and IR and NMR spectroscopy.

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Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Solvent-Dependent Hemilability of (2-Diphenylphosphino)Phenol in a Ru(II) para-Cymene System

et al. 2018

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“…The MIC values of Schiff base cerium(IV) complex against B. subtilis, S. aureus, E. coli, and Pseudomonas fluorescens (P. fluorescens) ranged from 1.56 to 12.5 µg/ml. The inhibition activity of this cerium complex is weaker against B. subtilis, while stronger against other tested bacteria compared with penicillin (Sang et al, 2015). The Schiff base cerium(III) complex had stronger antibacterial activities against B. subtilis, S. aureus, E. coli, and P. fluorescens than the free Schiff base, and corresponding MIC values were in the range of 1.56 to 25 µg/ml (Sang et al, 2017).…”

Section: Cerium Complexesmentioning

confidence: 91%

“…Cerium complexes with various ligands possessed different properties, such as antitumor and antimicrobial activities (Sang et al, 2017). Schiff base cerium complexes were reported to have interesting antibacterial activity (Sang et al, 2015(Sang et al, , 2017. The MIC values of Schiff base cerium(IV) complex against B. subtilis, S. aureus, E. coli, and Pseudomonas fluorescens (P. fluorescens) ranged from 1.56 to 12.5 µg/ml.…”

Section: Cerium Complexesmentioning

confidence: 99%

“…In another study, the Schiff base cerium(III) complex was reported to exhibit antibacterial activity with all MIC values of > 50 µg/ml against S. aureus, K. pneumonia, E. coli, P. vulgaris, and Candida albicans (C. albicans) (El-Shafiy and Shebl, 2018). The lipophilicity of the complex made it easier to penetrate into the lipid membrane and block the metal binding sites on enzymes of bacteria (Sang et al, 2015). In addition, the complex NaCe(MoO 4 ) 2 could act as antibiotic activity "modulators, " increasing the activity of a specific antibiotic for a certain strain.…”

Section: Cerium Complexesmentioning

confidence: 99%

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Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has helped to cure numerous infectious diseases and made huge contributions in the biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to serious drug resistance for many human bacterial pathogens. In particular, bacterial drug resistance decreases therapeutic effects and leads to high mortality. Inspiringly, the introduction of nanomaterials in the biomedical field makes it possible to overcome the difficulty in bacterial drug resistance attributed to their unique antibacterial mechanism. Recently, a variety of metal-and metal oxide-based nanomaterials have been fully integrated in antibacterial applications and achieved excellent performances. Among them, cerium-and cerium oxide-based nanomaterials have received much attention worldwide. Remarkably, cerium oxide nanoparticles with lower toxicity act as effective antibacterial agents owing to their unique functional mechanism against pathogens through the reversible conversion of oxidation state between Ce(III) and Ce(IV). This article provides an overview of the state-of-the-art design and antibacterial applications of cerium-and cerium oxidebased materials. The first part discusses the underlying antibacterial mechanisms for cerium-and cerium oxide-based materials currently applied in biomedicine. The second part focuses on various antibacterial-related materials and their applications. In addition, the existing problems and future perspectives of the cerium-and cerium oxide-based materials make up the third part of this review. This paper could provide the possible mechanisms for antibacterial activities, various designs of cerium-and cerium oxide-based materials, and related antibacterial properties.

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Lanthanoid Complexes as Molecular Materials: The Redox Approach

Hay

Boskovic

2021

Chemistry A European J

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The development of molecular materials with novel functionality offers promise for technological innovation. Switchable molecules that incorporate redox‐active components are enticing candidate compounds due to their potential for electronic manipulation. Lanthanoid metals are most prevalent in their trivalent state and usually redox‐activity in lanthanoid complexes is restricted to the ligand. The unique electronic and physical properties of lanthanoid ions have been exploited for various applications, including in magnetic and luminescent materials as well as in catalysis. Lanthanoid complexes are also promising for applications reliant on switchability, where the physical properties can be modulated by varying the oxidation state of a coordinated ligand. Lanthanoid‐based redox activity is also possible, encompassing both divalent and tetravalent metal oxidation states. Thus, utilization of redox‐active lanthanoid metals offers an attractive opportunity to further expand the capabilities of molecular materials. This review surveys both ligand and lanthanoid centered redox‐activity in pre‐existing molecular systems, including tuning of lanthanoid magnetic and photophysical properties by modulating the redox states of coordinated ligands. Ultimately the combination of redox‐activity at both ligands and metal centers in the same molecule can afford novel electronic structures and physical properties, including multiconfigurational electronic states and valence tautomerism. Further targeted exploration of these features is clearly warranted, both to enhance understanding of the underlying fundamental chemistry, and for the generation of a potentially important new class of molecular material.

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Synthesis, crystal structure and antibacterial activity of a novel phenolato- and peroxo-bridged dinuclear cerium(IV) complex with tripodal Schiff bases

Cited by 18 publications

References 31 publications

Solvent-Dependent Hemilability of (2-Diphenylphosphino)Phenol in a Ru(II) para-Cymene System

Solvent-Dependent Hemilability of (2-Diphenylphosphino)Phenol in a Ru(II) para-Cymene System

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Lanthanoid Complexes as Molecular Materials: The Redox Approach

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