Synthesis, crystal structure and biological activity of 1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone and its cobalt complex

Synthesis, spectroscopic characterization, crystal structures, and theoretical studies of (E)-2-(2,4-dimethoxybenzylidene)thiosemicarbazone and (E)-2-(2,5-dimethoxybenzylidene)thiosemicarbazone

“…They have been evaluated over the last 50 years as antiviral, antibacterial, and anticancer therapeutics, and biological activities of them are a function of parent aldehyde or ketone moiety [2][3][4][5][6][7]. Thiosemicarbazone is an important group of multidentate ligands and usually coordinates with the metal through the imine nitrogen and sulfur atom [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] (Scheme 1).…”

Molecular structures and spectroscopic characterization of cobalt(III) and nickel(II) complexes of N-(2-hydroxyethyl)-2-(thiophene-2-ylmethylene)-hydrazinecarbothioamide

“…Six adjacent molecules are situated on hexangular vertices, and and C6=N2 (1.319(3) Å ) bond distances. The C6-S1 bond length is 1.739(2) Å , which is shorter than 1.82 Å for a C-S bond and longer than 1.56 Å for a C-S bond [28,29], supporting the suggestion that the complex formation involves the ligand in its thiol form. Further, this bond length is longer than that of a typical C-S double bond found in free thiosemicarbazones e.g., 1.687(3) Å in 3-thiophenealdehyde thiosemicarbazone [20], 1.704(5) Å in ferrocene-1-carbaldehyde thiosemicarbazone [32], 1.704(3) Å 4-methylbenzaldehyde thiosemicarbazone [33] and 1.693(2) Å in (E)-4-octyloxybenzaldehyde thiosemicarbazone [34], which is another evidence for the thiolate form in the complex.…”

“…The C6-S1 bond distance is (1.736(6) Å ), with which is shorter than a C-S single bond of 1.82 Å but longer than a C=S double bond of 1.56 Å [28,29]. This is an indication that there is some electron delocalization in the thiosemicarbazide chain, conferring a partial double bond character [30].…”

Synthesis and Characterization of N1-Phenylhydrazine-1,2-bis(carbothioamide) and Its Evaluation for Antimicrobial, Antioxidant, and Brine Shrimp Lethality Bioassay

“…Thiosemicarbazone, a large group of thiourea derivatives, exhibits various biological activities and has therefore attracted considerable pharmaceutical interest [1]. They have been evaluated as antiviral [2], antioxidant [3], antibacterial [4,5], antitumor [6,7], anticancer [8,9], and antitubercular [10][11][12] therapeutics over the last 50 years, whose biological activities are a function of parent aldehyde or ketone moiety [13]. Thiosemicarbazones are potent intermediates for the synthesis of pharmaceutical and bioactive materials, and, thus, they are used extensively in the field of medicinal chemistry [14].…”