Synthesis, crystal structure, and BSA binding studies of new Co(II) and Ni(II) complexes of 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylate

Li, Xiaofei; Yang, Yanqiu; Li, Ya-Xue; Yang, Huai-Xia; Zhao, Wenfeng; Meng, Xiangru

doi:10.1016/j.ica.2020.119469

Cited by 17 publications

(8 citation statements)

References 33 publications

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“…Complex 2 exhibits higher BSA quenching abilities than complex 1 [38]. The quenching mechanism can be confirmed by means of the Stern-Volmer Equation (1) [3]:…”

Section: Interaction Between Complexes and Albumins 221 Interaction B...mentioning

confidence: 71%

“…The quenching mechanism can be confirmed by means of the Stern–Volmer Equation (1) [ 3 ]: ( F 0 − F )/ F = K q τ 0 [Q] = K sv [Q] …”

Section: Resultsmentioning

confidence: 99%

“…Serum albumin (SAs) are abundant in human plasma and are often used as model proteins for studying protein–drug interactions since they can convey many endogenous and exogenous drugs [ 1 , 2 , 3 ]. The interaction of SA with potentially bioactive compounds can affect the distribution, storage, transport, pharmacodynamics, and metabolism of drugs in living organism.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Guo¹,

Wang³

et al. 2022

Molecules

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Imidazole and tetrazole derivatives are widely used as clinical drugs since they possess a variety of pharmaceutical function. Zinc and iron are essential trace elements of the human body, with less toxicity and good biocompatibility. In this paper, two new essential metal mononuclear complexes [M(H2tmidc)2(H2O)2]·2H2O (M = Zn (1), Fe (2)) were synthesized through the reaction of 2-((1H-tetrazol-1-yl)methylene)-1H-imidazole-4,5-dicarboxylic acid (H3tmidc) and ZnSO4·7H2O or FeSO4·7H2O. The crystal structures were determined by means of the X-ray single crystal diffraction technique. Results from fluorescence investigations show that both complexes could interact with BSA as well as HSA through the static quenching mechanism. van der Waals forces and hydrogen bonds play important roles in the interaction of complexes and BSA/HSA since both ΔH and ΔS values are negative. The results of molecular docking are consistent with those in experimental studies. Furthermore, the anticancer activity of H3tmidc and both complexes against Eca-109 were preliminarily evaluated and the results show that both complexes have better anticancer activity than the corresponding ligand H3tmidc.

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“…Complex 2 exhibits higher BSA quenching abilities than complex 1 [38]. The quenching mechanism can be confirmed by means of the Stern-Volmer Equation (1) [3]:…”

Section: Interaction Between Complexes and Albumins 221 Interaction B...mentioning

confidence: 71%

“…The quenching mechanism can be confirmed by means of the Stern–Volmer Equation (1) [ 3 ]: ( F 0 − F )/ F = K q τ 0 [Q] = K sv [Q] …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Guo¹,

Wang³

et al. 2022

Molecules

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“…It is well known that imidazole, tetrazole and their derivatives have been widely used as excellent building blocks for the preparation of complexes since they coordinate with most of metal ions with diverse coordination modes [4][5][6][7][8][9][10]. The N-heterocyclic carboxylic acid, 2-(1Htetrazol-1-methyl)-1H-imidazole-4,5-dicarboxylic acid and the deprotonated anions are excellent ligands as there are potential N-donors and O-donors.…”

Section: Commentmentioning

confidence: 99%

Crystal structure of catena-poly[triqua-bis(μ ₂-4-carboxy-2-(1H-tetrazol-1-yl)-1H-imidazole-5-carboxylato-k³ N,O:O′)barium(II)] tetrahydrate, C₁₄H₁₄BaN₁₂O₁₅

Xie

Wang³

2020

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Bovine serum albumin (BSA) is a biocompatible globulin in bovine serum, which has wide applications in nanomedicine [22][23][24][25][26]. The hydrophobic region on the protein is feasible for loading hydrophobic chemodrug such as DOX [27][28][29][30], while its abundant amino and cysteine groups tend to attach metal ions such as copper ions [31,32]. However, the metal ions attached to albumin are prone to uncontrolled release without speci city, leading to unsatisfactory copper dosages for CDT and latent toxicity issues [33,34].…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment-Responsive BSA Nanocarriers For Combined Chemo/Chemodynamic Cancer Therapy

Zhang

Teng²,

et al. 2022

Preprint

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Tumor microenvironment (TME), characterized by high glutathione (GSH), high hydrogen peroxide (H2O2) and low acidic levels, is favorable for the growth, invasion and metastasis of cancer cells. Taking advantage of the specific characteristics of tumors, TME-responsive GCBD NPs are designed to deliver nanoscale coordination polymers (NCPs, GA-Cu) and chemotherapy drugs (doxorubicin, DOX) based on bovine serum albumin (BSA) nanocarriers into cancer cells for combined chemodynamic therapy (CDT) and chemotherapy. In an acidic environment, GCBD NPs could release approximately 90% copper ions, which can not only consume overexpressed GSH to modulate the TME but can also react with endogenous H2O2 in a Fenton-like reaction to achieve the CDT effect. Meanwhile, the released DOX could enter the nucleus of tumor cells and affect their proliferation to achieve efficient chemotherapy. Both in vitro and in vivo experiments showed that GCBD NPs had good biosafety and could effectively inhibit the growth of cancer cells. GCBD NPs are promising as a biocompatible nanoplatform to exploit TME characteristics for combined chemo and chemodynamic therapy, providing a novel strategy to eradicate tumors with high efficiency and specificity.

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Synthesis, crystal structure, and BSA binding studies of new Co(II) and Ni(II) complexes of 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylate

Cited by 17 publications

References 33 publications

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Crystal structure of catena-poly[triqua-bis(μ ₂-4-carboxy-2-(1H-tetrazol-1-yl)-1H-imidazole-5-carboxylato-k³ N,O:O′)barium(II)] tetrahydrate, C₁₄H₁₄BaN₁₂O₁₅

Tumor Microenvironment-Responsive BSA Nanocarriers For Combined Chemo/Chemodynamic Cancer Therapy

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Synthesis, crystal structure, and BSA binding studies of new Co(II) and Ni(II) complexes of 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylate

Cited by 17 publications

References 33 publications

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

Crystal structure of catena-poly[triqua-bis(μ 2-4-carboxy-2-(1H-tetrazol-1-yl)-1H-imidazole-5-carboxylato-k3 N,O:O′)barium(II)] tetrahydrate, C14H14BaN12O15

Tumor Microenvironment-Responsive BSA Nanocarriers For Combined Chemo/Chemodynamic Cancer Therapy

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Product

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Crystal structure of catena-poly[triqua-bis(μ ₂-4-carboxy-2-(1H-tetrazol-1-yl)-1H-imidazole-5-carboxylato-k³ N,O:O′)barium(II)] tetrahydrate, C₁₄H₁₄BaN₁₂O₁₅